MICROSCOPIC AND MORPHOMETRIC CHANGES IN THE PULMONARY MICROVASCULATURE OF LABORATORY RATS THREE HOURS AFTER ADMINISTRATION OF LEIURUS MACROCTENUS SCORPION VENOM

Authors:

Abstract:

Three hours after administration of Leiurus macroctenus scorpion venom, pronounced structural and functional disturbances of the microcirculatory bed develop in the lungs of laboratory rats. Among the microscopic changes, marked congestion of small-caliber vessels predominates, combined with their narrowing caused by edema of both the vascular walls and the stromal component of the lung. In addition, a pronounced inflammatory reaction is observed, characterized by massive leukocyte migration with a predominance of segmented neutrophils and activation of basophils in the perivascular space. Disruption of vascular wall integrity is accompanied by various microscopic alterations, including structural disorganization, stratification, and the development of perivascular edema. In most fields of view, pulmonary tissue demonstrates foci of hemorrhage and fibrin thrombi formation in small-caliber vessels. Morphometric analysis confirms a statistically significant decrease in the internal diameter of arterioles, capillaries, and venules (p=0.004, p=0.007, and p=0.0002, respectively) compared with the control group. The overall spectrum of identified microscopic changes indicates the development of acute inflammatory and thrombohemorrhhagic disturbances of blood circulation in the small pulmonary vessels in response to the toxic effect of Leiurus macroctenus scorpion venom.

Keywords:

pulmonary microvessels of laboratory rats the effects of Leiurus macroctenus scorpion venom morphological and morphometric changes

References:

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Publication:

«World of Medicine and Biology» Vol. 22 No. 1 (2026) , с. 180-184
УДК 616.514-037:572.087+612-071

DOI:

https://doi.org/10.26724/2079-8334-2026-1-95-180-184