FROZEN-DRIED HUMAN CORD BLOOD LEUKOCONCENTRATE AS A DRIVER OF HSP70 PROTEIN EXPRESSION AND TOLEROGENIC DENDRITIC CELLS FORMATION

Authors:

Abstract:

Dendritic cells play a leading role in regulating the immune response, particularly in the induction of immune tolerance. The heat shock protein Hsp70 is known for its immunomodulatory properties. To date, its participation in the formation of the tolerogenic phenotype and function of dendritic cells remains poorly understood. The effect of frozen-dried human cord blood leukoconcentrate on the expression of Hsp70 protein in dendritic cells and the associated changes in their functional state was analyzed. The dose-dependent ability of frozen-dried human cord blood leukoconcentrate to induce Hsp70 expression in dendritic cells derived from mouse bone marrow mononuclear cells was established, indicating its regulatory potential. It has been shown that, under the influence of frozen-dried human cord blood leukoconcentrate, the expression of the Hsp70 protein in dendritic cells increases, thereby enhancing their tolerogenic function by increasing the production of the anti-inflammatory cytokine IL-10. The results emphasize the key role of the Hsp70 protein in inducing immune tolerance and also open up prospects for the use of frozen-dried human cord blood leukoconcentrate in the treatment of autoimmune pathologies.

Keywords:

tolerogenic dendritic cells frozen-dried human cord blood leukoconcentrate Hsp70 protein IL-10

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Publication:

«World of Medicine and Biology» Vol. 22 No. 1 (2026) , с. 185-189
УДК 577.322.23:611.018.46:612.017:611.018.53.088:618.48

DOI:

https://doi.org/10.26724/2079-8334-2026-1-95-185-189