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Experemental medicine

EFFECT OF HYDROGEN SULFIDE AND CYSTEINE ON AORTIC TONE IN RATS WITH DIFFERENT THYROID STATUS

Published 2026-02-04

Authors:

V.M. Nechiporuk
National Pirogov Memorial Medical University, Vinnytsya image/svg+xml
https://orcid.org/0000-0002-0744-9236
A.V. Melnyk
National Pirogov Memorial Medical University, Vinnytsya image/svg+xml
https://orcid.org/0000-0003-1315-7958
N.I. Voloshchuk
National Pirogov Memorial Medical University, Vinnytsya image/svg+xml
https://orcid.org/0000-0002-0166-9676
I.V. Slieptsova
National Pirogov Memorial Medical University, Vinnytsya image/svg+xml
O.S. Pashynska
National Pirogov Memorial Medical University, Vinnytsya image/svg+xml
https://orcid.org/0000-0001-5485-9898
O.O. Nefodov
Odesa I. I. Mechnikov National University image/svg+xml
https://orcid.org/0000-0002-5796-1852
M.M. Korda
I.Horbachevsky Ternopil National Medical University image/svg+xml
https://orcid.org/0000-0003-0676-336X
Abstract:
Impaired thyroid function is recognized as a major contributor to endothelial dysfunction and cardiovascular disease. This study examined the vascular effects of sulfur-containing compounds in rats with experimentally induced hypothyroidism and hyperthyroidism. Thoracic aortic segments were analyzed to assess contractile responses to cysteine and hydrogen sulfide. The results demonstrated that hypothyroidism significantly reduced vascular relaxation, as shown by a rightward shift of dose-response curves and increased effective concentrations of the test substances. In contrast, hyperthyroidism did not produce notable changes in vascular tone. These findings indicate that thyroid hormone deficiency leads to pronounced endothelial dysfunction manifested as diminished sensitivity of the vascular wall to vasodilators. The study expands understanding of molecular mechanisms regulating vascular tone under endocrine disorders and suggests new therapeutic targets for cardiovascular conditions associated with thyroid dysfunction.
Keywords:
hyperthyroidism hypothyroidism hydrogen sulfide cysteine vascular tone aorta
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Publication:
«World of Medicine and Biology» Vol. 22 No. 1 (2026) , с. 203-207
УДК 577.1:661.29:577.112.3:599.323.4
DOI:
https://doi.org/10.26724/2079-8334-2026-1-95-203-207