EFFECT OF A THERAPEUTIC AND PREVENTIVE COMPLEX ON THE BIOCHEMICAL INDICATORS OF THE MUCOUS MEMBRANE OF RATS’ GUMS UNDER CONDITIONS OF A CARIES-INDUCING DIET AND DIETARY VITAMIN D DEFICIENCY ON THE BACKGROUND OF JAW BONE TISSUE DESTRUCTION

Authors:

Abstract:

The study was devoted to assessing the effect of the proposed therapeutic and prophylactic regimen on the biochemical parameters of the gingival mucosa in rats under conditions of a cariogenic diet and dietary vitamin D deficiency against a background of jawbone destruction. Experimental studies were conducted on 30 four-month-old Wistar rats. During the experiment, the animals were divided into three groups of 10 rats each: Group 1 – intact; Group 2 – trauma to the lower jaw region in the projection of the molar roots and modeling of dietary vitamin D deficiency against a background of a high-sugar cariogenic diet; Group 3 – pathology model and application of a therapeutic-preventive complex. Gingival homogenates were prepared, and levels of biochemical markers of systemic inflammation were determined: elastase activity and malondialdehyde content, as well as urease, lysozyme, and catalase activity. The therapeutic and preventive use of the proposed complex in rats contributes to the inhibition of the identified disorders, normalizing the studied parameters to the levels of intact animals, which indicates the pronounced antioxidant, anti-inflammatory, and antimicrobial properties of the complex.

Keywords:

bone destruction rats vitamin D deficiency dental caries biochemical parameters of the gums experiment

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Publication:

«World of Medicine and Biology» Vol. 22 No. 1 (2026) , с. 208-213
УДК [57.084.1+616.311.2+611.018.4+616.314-002]:616-08-039.71

DOI:

https://doi.org/10.26724/2079-8334-2026-1-95-208-213