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Experemental medicine

EXPERIMENTAL STUDY OF THE EMBRYO- AND CARDIOPROTECTIVE ROLE OF ZINC SUCCINATE IN RELATION TO CADMIUM CHLORIDE TOXICITY

Published 2026-02-04

Authors:

V.F. Shatorna
Dnipro State Medical University image/svg+xml
https://orcid.org/0000-0002-5853-9864
T.V. Svyatenko
Dnipro State Medical University image/svg+xml
https://orcid.org/0000-0003-4303-2937
L.L. Lomyha
Dnipro State Medical University image/svg+xml
https://orcid.org/0000-0002-7881-1386
Abstract:
Cardiovascular diseases remain the leading causes of mortality worldwide and in Ukraine. The current direction of modern morphological research is to determine the changes that occur in vivo under the influence of cadmium compounds on the fertilization process, embryogenesis, and formation and development of the heart. The aim of the experiment was to determine changes in heart morphogenesis and the main indicators of embryogenesis under conditions of chronic daily exposure to cadmium chloride with isolated administration and in combination with zinc succinate. The data obtained demonstrated a complex, dose-dependent nature of the interaction of cadmium chloride with the essential trace element zinc succinate. In the heart tissues of adult female rats and its embryos, the level of cadmium accumulation decreased with the combined administration of the studied substances. Also, the simultaneous administration of zinc succinate with cadmium chloride significantly reduced the effects of embryo- and cardiotoxicity of cadmium, which allows us to consider zinc succinate as a potential protector or bioantagonist of the toxic properties of cadmium chloride in the studied doses and method of administration in the experiment on rats.
Keywords:
rats heart embryo cardiotoxicity cadmium zinc succinates experiment
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Publication:
«World of Medicine and Biology» Vol. 22 No. 1 (2026) , с. 219-224
УДК 611.12–053.13:546.48’131:546.461.4:616–091.8–092.9
DOI:
https://doi.org/10.26724/2079-8334-2026-1-95-219-224