Reviews
GLOBAL TRENDS AND RISK FACTORS OF LOW BIRTH WEIGHT
Published
2026-02-04
Authors:
UA
SG
GH
GN
- Abstract:
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Low birth weight, defined as a birth weight below 2500 grams, remains a major global health concern, especially in low- and middle-income countries, where over 95 % of cases with low birth weight occur. This review synthesizes current global and regional trends, prevalence estimates, and associated risk factors for low birth weight based on data from WHO, UNICEF, and peer-reviewed studies. Key determinants include preterm birth, intrauterine growth restriction, maternal undernutrition, anemia, socioeconomic status, and limited access to quality antenatal care. Despite advances in healthcare, progress toward reducing low birth weight has been slow and uneven across regions. The review underscores the need for improved data quality, targeted interventions, and comprehensive maternal health strategies to reduce low birth weight-related mortality and long-term complications. Strengthening perinatal care, improving maternal education, and addressing social determinants are essential steps toward achieving global child health targets.
- Keywords:
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low birth weight neonatal mortality maternal health risk factors socioeconomic determinants
- References:
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- Ailbayeva N, Аlimbaeva A, Rakhyzhanova S, Kudaibergenova N, Berikuly D, Tanatarov S, et al. The impact of birth weight on infant mortality in Kazakhstan. Georgian Med News. 2024;(351):138-145. PMID: 39230236.
- Alhasoon M. Prevalence of and Risk Factors for Extremely Low Birth Weight Infants in Saudi Arabia: A Four-Year Single-Center Experience. Cureus. 2025 Jun 1;17(6):e85202. doi: 10.7759/cureus.85202.
- Bandyopadhyay A, Jones H, Parker M, Marchant E, Evans J, Todd C, et al. Weighting of risk factors for low birth weight: a linked routine data cohort study in Wales, UK. BMJ Open. 2023 Feb 10;13(2):e063836. doi: 10.1136/bmjopen-2022-063836.
- Biks GA, Blencowe H, Hardy VP, Geremew BM, Angaw DA, Wagnew A, et al. Every Newborn-INDEPTH Study Collaborative Group (2021). Birthweight data completeness and quality in population-based surveys: EN-INDEPTH study. Population health metrics. 2021; 19(Suppl 1), 17. https://doi.org/10.1186/s12963-020-00229-w.
- Bradley E, Blencowe H, Moller AB, Okwaraji YB, Sadler F, Gruending A, et al. Born too soon: global epidemiology of preterm birth and drivers for change. Reprod Health. 2025 Jun 23;22(Suppl 2):105. doi: 10.1186/s12978-025-02033-x.
- Bridgeman-Bunyoli AM, Cheyney M, Monroe SM, Wiggins N, Vedam S. Preterm and low birthweight birth in the United States: Black midwives speak of causality, prevention, and healing. Birth. 2022;49(3):526-539. doi:10.1111/birt.12624.
- Chasekwa B, Ntozini R, Church JA, Majo FD, Tavengwa N, Mutasa B, et al; Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial Team. Prevalence, risk factors and short-term consequences of adverse birth outcomes in Zimbabwean pregnant women: a secondary analysis of a cluster-randomized trial. Int J Epidemiol. 2022 Dec 13;51(6):1785-1799. doi: 10.1093/ije/dyab248.
- Curtis DS, Fuller-Rowell TE, Carlson DL, Wen M, Kramer MR. Does a Rising Median Income Lift All Birth Weights? County Median Income Changes and Low Birth Weight Rates Among Births to Black and White Mothers. Milbank Q. 2022;100(1):38-77. doi:10.1111/1468-0009.12532.
- Diabelková J, Rimárová K, Urdzík P, Dorko E, Houžvičková A, Andraščíková Š, et al. Risk factors associated with low birth weight. Cent Eur J Public Health. 2022 Jun;30(Supplement):S43-S49. doi: 10.21101/cejph.a6883.
- Erchick DJ, Hazel EA, Katz J, Lee ACC, Diaz M, Wu LSF, et al. Subnational Vulnerable Newborn Prevalence Collaborative Group and Vulnerable Newborn Measurement Core Group. Vulnerable newborn types: analysis of subnational, population-based birth cohorts for 541 285 live births in 23 countries, 2000-2021. BJOG. 2025 Nov;132 Suppl 8(Suppl 8):S20-S36. doi: 10.1111/1471-0528.17510.
- Girotra S, Mohan N, Malik M, Roy S, Basu S. Prevalence and Determinants of Low Birth Weight in India: Findings From a Nationally Representative Cross-Sectional Survey (2019-21). Cureus. 2023;15(3):e36717. Published 2023 Mar 26. doi:10.7759/cureus.36717.
- Heller G, Rossi R, Thomas T. Zum Beitrag: Qualität der Versorgung sehr kleiner Frühgeborener in Deutschland – Auswertung öffentlich verfügbarer Daten der Perinatalzentren von 2014 bis 2018. Z Geburtshilfe Neonatol. 2021;225(5):447-448. doi:10.1055/a-1549-1718.
- Huang Z, Zhang Q, Zhu L, Xiang H, Zhao D, Yao J. Determinants of low birth weight among newborns delivered in China: a prospective nested case-control study in a mother and infant cohort. J Obstet Gynaecol. 2023;43(1):2197483. doi:10.1080/01443615.2023.2197483.
- Kamali M, Wright JE, Akseer N, Tasic H, Conway K, Brar S, et al. Trends and determinants of newborn mortality in Kyrgyzstan: a Countdown country case study. Lancet Glob Health. 2021 Mar;9(3):e352-e360. doi: 10.1016/S2214-109X(20)30460-5.
- Kasuga Y, Ikenoue S, Tamagawa M, Oishi M, Endo T, Sato Y, et al. What are the causes for low birthweight in Japan? A single hospital-based study. PLoS One. 2021 Jun 23;16(6):e0253719. doi: 10.1371/journal.pone.0253719.
- Khan S, Baloch FN, Bosan R, Khan A, Khan M, Punar ZA, et al. Frequency of Low Birth Weight Neonates in Mothers with Low Serum Ferritin Levels: Frequency of Low Birth Weight Neonates in Mothers. Pakistan Journal of Health Sciences. 2025; 6(3), 60–66. https://doi.org/10.54393/pjhs.v6i3.2702.
- Krasevec J, Blencowe H, Coffey C, Okwaraji YB, Estevez D, Stevens GA, et al. Study protocol for UNICEF and WHO estimates of global, regional, and national low birthweight prevalence for 2000 to 2020. Gates Open Res. 2022 Jul 19;6:80. doi: 10.12688/gatesopenres.13666.1.
- Kraus V, Schatz U, Krüger M, Krampe-Heni F. Characterization of Neonatal Seizures in a Large Well-defined Multicenter Cohort of a Tertiary Neonatology Center in Germany. Neuropediatrics. 2026 Feb;57(1):35-41. doi: 10.1055/a-2710-4474.
- Kubio C, Abanga WA, Zeng V, Bosoka SA, Afetor M, Djokoto SK, et al. Incidence of low birth weight among newborns delivered in health facilities in the Volta Region, 2019-2023. BMC Pregnancy Childbirth. 2025 Apr 26;25(1):511. doi: 10.1186/s12884-025-07639-4.
- Lawn JE, Ohuma EO, Bradley E, Idueta LS, Hazel E, Okwaraji YB, et al; Lancet Small Vulnerable Newborn Steering Committee; WHO/UNICEF Preterm Birth Estimates Group; National Vulnerable Newborn Measurement Group; Subnational Vulnerable Newborn Measurement Group. Small babies, big risks: global estimates of prevalence and mortality for vulnerable newborns to accelerate change and improve counting. Lancet. 2023 May 20;401(10389):1707-1719. doi: 10.1016/S0140-6736(23)00522-6.
- Le Vu M, Matthes KL, Brabec M, Riou J, Skrivankova VW, Hösli I, et al. Health of singleton neonates in Switzerland through time and crises: a cross-sectional study at the population level, 2007-2022. BMC Pregnancy Childbirth. 2024 Mar 25;24(1):218. doi: 10.1186/s12884-024-06414-1.
- Ma L, Li X, Wang M, Cao D, Yan Q. Trends in Mortality of Low Birth Weight Infants - China, 2004-2019. China CDC Wkly. 2022;4(20):431-436. doi:10.46234/ccdcw2022.038.
- Mare KU, Andarge GG, Sabo KG, Mohammed OA, Mohammed AA, Moloro AH, et al. Regional and sub-regional estimates of low birth weight and its determinants in 44 low- and middle-income countries: evidence from demographic and health survey data. BMC Pediatr. 2025 May 1;25(1):342. doi: 10.1186/s12887-025-05691-9.
- Miyazawa T, Arahori H, Ohnishi S, Shoji H, Matsumoto A, Wada YS, et al. Mortality and morbidity of extremely low birth weight infants in Japan, 2015. Pediatr Int. 2023 Jan;65(1):e15493. doi: 10.1111/ped.15493.
- Mohamoud JH, Mahmoud AA, Adan RA, Mohamed AMS, Adam MH. Magnitude of Low Birth Weight and Associated Factors Among Newborns Delivered in Public Hospitals of Benadir Region, Somalia: A Facility-Based Cross-Sectional Study. Sage Open Pediatrics. 2025;12. doi:10.1177/30502225251321023.
- Nabila M, Baidani A, Mourajid Y, Chebabe M, Abderraouf H. Analysis of Risk Determinants of Neonatal Mortality in the Last Decade: A Systematic Literature Review (2013-2023). Pediatr Rep. 2024;16(3):696-716. Published 2024 Aug 12. doi:10.3390/pediatric16030059.
- Ohuma EO, Moller A-B, Bradley E, Althabe F, Boyle EM, Costello A, et al. National, regional, and worldwide estimates of preterm birth in 2020, with trends from 2010: a systematic analysis. Lancet. 2023;402(10409):1261-71. doi:10.1016/S0140-6736(23)00878-4.
- Okwaraji YB, Krasevec J, Bradley E, Conkle J, Stevens GA, Gatica-Domínguez G, et al. National, regional, and global estimates of low birthweight in 2020, with trends from 2000: a systematic analysis. Lancet. 2024 Mar 16;403(10431):1071-1080. doi: 10.1016/S0140-6736(23)01198-4.
- Oralkhan Zh, Sarsenova L, Kopbayeva M, Tastambek K, Grjibovski AM, Berdalinova A, et al. Maternal correlates of spontaneous preterm birth in Kazakhstan: a matched case-control study. Human Ecology. 2023;30(12):901–8. https://doi.org/10.17816/humeco629001.
- Perin J, Mulick A, Yeung D, Villavicencio F, Lopez G, Strong KL, et al. Global, regional, and national causes of under-5 mortality in 2000-19: an updated systematic analysis with implications for the Sustainable Development Goals. Lancet Child Adolesc Health. 2022 Feb;6(2):106-115. doi: 10.1016/S2352-4642(21)00311-4.
- Perrin T, Pradat P, Larcade J, Masclef-Imbert M, Pastor-Diez B, Picaud JC. Postnatal growth and body composition in extremely low birth weight infants fed with individually adjusted fortified human milk: a cohort study. Eur J Pediatr. 2023 Mar;182(3):1143-1154. doi: 10.1007/s00431-022-04775-3.
- Putri AP, Alia A, Sinaga J, Harsanti A, Sabur RP, Salsabila NK. Frequency and risk factors associated with Low Birth Weight (LBW) at Bandung Regional General Hospital Indonesia. International Journal of Health Sciences. 2025; 9(1), 124–132. https://doi.org/10.53730/ijhs.v9n1.15503.
- Suárez-Idueta L, Blencowe H, Okwaraji YB, Yargawa J, Bradley E, Gordon A, et al; National Vulnerable Newborn Mortality Collaborative Group and Vulnerable Newborn Measurement Core Group. Neonatal mortality risk for vulnerable newborn types in 15 countries using 125.5 million nationwide birth outcome records, 2000-2020. BJOG. 2025 Nov;132 Suppl 8(Suppl 8):S37-S47. doi: 10.1111/1471-0528.17506.
- Suzuki S, Itakura A, Takeda J, Morisaki N. Recent Status of Low-Birth-Weight Infants in Japan. Cureus. 2025 Mar 22;17(3):e81008. doi: 10.7759/cureus.81008.
- Trerotoli P, Bartolomeo N, Leogrande S, Triggiani S, Mincuzzi A, Serio G, et al. Survey of Low Birthweight and Extremely Low Birthweight Events in a High Environmental Risk Area of Apulia, Italy. Int J Environ Res. 2021; 15, 11–17. https://doi.org/10.1007/s41742-020-00294-x.
- Trotter A. Qualität der Versorgung sehr kleiner Frühgeborener in Deutschland – Auswertung öffentlich verfügbarer Daten der Perinatalzentren von 2014 bis 2018 [Quality of Care for Very Low Birth Weight Infants in Germany - Evaluation of Publicly Available Data from 2014 to 2018]. Z Geburtshilfe Neonatol. 2021;225(1):74-79. doi:10.1055/a-1350-3953. [in German].
- UN Inter-Agency Group for Child Mortality Estimation Levels and Trends in Child Mortality: Report 2022. [(accessed on 12 March 2023)]; Available online: https://data.unicef.org/resources/levels-and-trends-in-child-mortality-2023.
- UNICEF Data: Monitoring the situation of children and women. Low birthweight. July 2023. https://data.unicef.org/topic/nutrition/low-birthweight/#resources.
- Vera-Ponce VJ, Loayza-Castro JA, Ballena-Caicedo J, Valladolid-Sandoval LAM, Zuzunaga-Montoya FE, Gutierrez De Carrillo CI. Global prevalence of preeclampsia, eclampsia, and HELLP syndrome: a systematic review and meta-analysis. Front Reprod Health. 2025 Nov 10;7:1706009. doi: 10.3389/frph.2025.1706009.
- World Health Organization (WHO). Preterm birth [Internet]. 2022 [cited 2025 Feb 13]. Available from: https://www.who.int/news-room/fact-sheets/detail/preterm-birth.
- Wulandari RD, Laksono AD, Matahari R. Policy to Decrease Low Birth Weight in Indonesia: Who Should Be the Target?. Nutrients. 2023;15(2):465. Published 2023 Jan 16. doi:10.3390/nu15020465.
- Yerdessov N, Zhamantayev O, Bolatova Z, Nukeshtayeva K, Kayupova G, Turmukhambetova A. Infant Mortality Trends and Determinants in Kazakhstan. Children (Basel). 2023 May 24;10(6):923. doi: 10.3390/children10060923.
- Zheng S, Cao Y, Strasser S, Wei H. Prevalence and risk factors of low birth weight in the United States: An analysis of 2016-2021 data. Am J Hum Biol. 2024;36(4):e24016. doi:10.1002/ajhb.24016.
- Publication:
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«World of Medicine and Biology»
Vol. 22 No. 1 (2026)
, с. 225-231
УДК 616-053.31-056.7:614.1
How to Cite
GLOBAL TRENDS AND RISK FACTORS OF LOW BIRTH WEIGHT. (2026). World of Medicine and Biology, 22(1), 225-231. https://doi.org/10.26724/2079-8334-2026-1-95-225-231
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