PSYCHO-NEUROTIC DISORDERS PREDETERMINANTS FROM THE PERSPECTIVE OF CLINICAL PATHOPHYSIOLOGY AND DIFFERENTIAL PSYCHOPHYSIOLOGY

Authors:

Abstract:

The purpose of the study was to highlight recent ideas regarding the predeterminants of the development of psychoneurotic disorders from an interdisciplinary perspective in integrative anthropology. This review highlights the leading determinants of the development of psycho-neurotic disorders from the perspectives of clinical pathophysiology and differential psychophysiology. A systematic analysis of studies from 2020 to 2025, taken from the medical databases PubMed, Google Scholar, Web of Science and SCOPUS, outlines four principal predeterminants associated with a high risk of psycho-neurotic disorders, especially, individual personality characteristics (premorbid distinctive character traits), genetic determination of the nervous system fundamental properties, environmental factors and dysregulation of nervous, endocrine and immune systems. The authors focus attention on the necessity of a systemic and integrative approach to identifying interindividual variability in psychological characteristics from the standpoints of clinical pathophysiology, psychogenetics, and differential psychophysiology. In their conclusion, the authors emphasize that pre-nosological diagnostics of borderline mental states and determination of the degree of risk of possible transition of psycho-neurotic disorders into neuroses should be based on taking into account the determinants of such disorders, which are a promising preventive direction for health preservation of broad segments of the Ukrainian population.

Keywords:

psycho-neurotic disorders predeterminants dysregulatory pathology clinical pathophysiology differential psychophysiology

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Publication:

«World of Medicine and Biology» Vol. 22 No. 1 (2026) , с. 239-246
УДК 612.821.159.938

DOI:

https://doi.org/10.26724/2079-8334-2026-1-95-239-246