TIME-STRATIFIED PROGNOSTIC VALUE OF ENDOTHELIAL BIOMARKERS IN ACUTE PANCREATITIS, WITH SOLUBLE E-SELECTIN AS AN EARLY MORTALITY PREDICTOR AND VON WILLEBRAND FACTOR AS A PREDICTOR OF ORGAN FAILURE

Authors:

Abstract:

Endothelial dysfunction contributes to severity in acute pancreatitis. Endothelial biomarkers were measured serially on days 1, 3, and 7 in 100 patients with acute pancreatitis. Biomarker patterns differed by clinical outcome and sampling time. In patients with worsened outcome, sE-selectin levels were highest on day 3 (87.35±1.97 ng/mL vs. 58.35±2.49 ng/mL in improved outcome), while von Willebrand factor levels showed divergence on day 7 (141.01±10.96 U/dL vs. 90.85±5.73 U/dL). ROC analysis suggested that day 3 sE-selectin ≥56.9 ng/mL might identify patients at risk for mortality (AUC 0.905; sensitivity 92.3 %, specificity 83.9 %), while day 7 von Willebrand factor ≥105 U/dL showed potential for identifying multiorgan dysfunction risk (AUC 0.746 (95 % CI: 0.596–0.896). sE-selectin elevations corresponded with early clinical worsening, while persistent von Willebrand factor elevation was associated with late organ dysfunction. These preliminary findings support further investigation of time-stratified biomarker assessment in larger, independent cohorts.

Keywords:

acute pancreatitis endothelial dysfunction biomarkers sE-Selectin von Willebrand factor

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Publication:

«World of Medicine and Biology» Vol. 22 No. 96 (2026) , с. 7-11
УДК 616.37-002-036.11-07:616.12-018.74

DOI:

https://doi.org/10.26724/2079-8334-2026-2-96-7-11