Clinical medicine
STATUS OF LIPID METABOLISM PARAMETERS, INTIMA-MEDIA COMPLEX THICKNESS, AND PERSONAL ANXIETY IN YOUNG PEOPLE WITH ARTERIAL HYPERTENSION AND OVERWEIGHT
Published
2026-05-13
Authors:
OB
IK
VD
OP
OP
LS
LA
- Abstract:
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The purpose of the study was to establish the relationship between lipid metabolism parameters, the condition of the vascular wall of the common carotid artery, and personal anxiety in young overweight patients with arterial hypertension. 76 patients (mean age 41.5±3.1 years) with grade 1–2 arterial hypertension who did not receive systematic drug therapy were examined, of which 45 had a normal body mass index (group 1) and 31 were overweight (group 2). All patients who did not receive systematic drug therapy showed a decrease in the level of psychological health, which was determined by high and moderate levels of reactive and personal anxiety. It was found that in patients with excess body weight, high levels of reactive and personal anxiety were determined in 58 % and moderate levels in 42 %. At the same time, in patients with normal body weight, an increase in the levels of reactive and personal anxiety to moderate was noted only in 33.3 %. Dyslipidemia was detected in 20 % of patients in group 1 and 51.6 % of group 2. Probable differences in lipid metabolism indicators were identified in patients with grade 1–2 arterial hypertension and increased body weight: an increase in total cholesterol, triglycerides, low-density lipoprotein cholesterol and a decrease in high–density lipoprotein cholesterol.It was demonstrated that in patients aged 25–44 years with arterial hypertension of 1–2 degrees, there was an increase in the content of C-reactive protein in the blood serum, but significant differences were found in patients with increased body weight. Also, in young people with arterial hypertension of 1–2 degrees, criteria for carotid artery remodeling were determined, according to the assessment of the thickness of the intima-media complex, which were significantly more pronounced in overweight individuals compared to the control group.
- Keywords:
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arterial hypertension in young people psychoemotional disorders excess body weight lipid metabolism C-reactive protein intima-media complex
- References:
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- Anderson JJ, Deo SV, Welsh P, MacKay DF, Ho FK, Ferguson LD. et al. In which common chronic conditions can (or cannot) obesity and lifestyle factors explain higher concentrations of C-reactive protein? Diabetes Obes Metab. 2024;26(12):5786-5794. doi: 10.1111/dom.15949.
- Bubulac L, Zivari M, Eremia IA, Erena C, Gheorghe CM, Gheorghe IR, Tudor V, Bogdan-Andreescu CF, Cadar E, Albu CC. Stress, Anxiety, and Self-Efficacy in Hypertension: Evidence from a Romanian Case-Control Study. Diseases. 2025 Nov 13;13(11):373. doi: 10.3390/diseases13110373.
- Dalakoti M, Chen CK, Sia CH, Poh KK. Frontiers in subclinical atherosclerosis and the latest in early life preventive cardiology. Singapore Med J. 2025 Mar 1;66(3):141-146. doi: 10.4103/singaporemedj.
- Huang X, Ye J, Liu S, Xu Z, Pan M, Lin J. et al. Association of Triglyceride-Glucose Body Mass Index with Target Organ Damage in Essential Hypertension: A Retrospective Cohort Study. J Clin Hypertens (Greenwich). 2025;27(8):e70114. doi: 10.1111/jch.70114.
- Johnson AE, Jackson CD, Alexander JT. Management of Hypertension in Adults. JAMA. 2026;335(16):1440-1441. doi: 10.1001/jama.2026.1132.
- Kandasamy G, Subramani T, Almanasef M, Orayj K, Shorog E, Alshahrani AM. et al. Mental health and hypertension: assessing the prevalence of anxiety and depression and their associated factors in a tertiary care population. Front. Public Health. 2025;13:1545386. doi: 10.3389/fpubh.2025.1545386.
- Lee J, Wang X, Liu C, Pathiravasan CH, Benjamin EJ, McManus DD. et al. Depressive symptoms are not associated with clinically important levels of digital home blood pressure in the electronic Framingham Heart Study. Cardiovasc Digit Health J. 2024;5(2):50-58. doi: 10.1016/j.cvdhj.2024.01.001.
- Meena D, Huang J, Dib MJ, Chirinos J, Jia M, Chauhan G, et al. Body Mass Index and Hypertension as Mediators of the Association Between Age at Menarche and Subclinical Atherosclerosis: A Sex-Specific Mendelian Randomization Analysis. J Am Heart Assoc. 2024;13(14):e032192. doi: 10.1161/JAHA.123.032192.
- Peczyńska J, Klonowska B, Żelazowska-Rutkowska B, Polkowska A, Noiszewska K, Bossowski A. et al. The Relationship between Selected Inflammation and Oxidative Stress Biomarkers and Carotid Intima-Media Thickness (IMT) Value in Youth with Type 1 Diabetes Co-Existing with Early Microvascular Complications. J. Clin. Med. 2022; 11: 4732. https://doi.org/10.3390/jcm11164732.
- Said B, Gharawi MO, Dallak FH, Maashi AQ, Hurissi E, Gharawi SO, et al. Factors Associated with Anxiety During COVID-19 Pandemic and Its Association with Hypertension in Saudi Arabia. Patient Prefer Adherence. 2023;17:905-912. doi: 10.2147/PPA.S400168.
- Tschiderer L, Seekircher L, Izzo R, Mancusi C, Manzi MV, Baldassarre D, et al. Proof-ATHERO Study Group. Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta-Analysis of 20 Prospective Studies. J Am Heart Assoc. 2023;12(12):e027657.
- Vyas A, Desai R, Patel V, Bansal P, Jain A, Gupta T, et al. Rising Burden of Cardiovascular Disease Risk Factors and Acute Cardiac Events in Young Adults With Comorbid Depression: A Comparison Nationwide US Cohorts Hospitalized 10-years Apart. Curr Probl Cardiol. 2023;48(8):101755. doi: 10.1016/j.cpcardiol.2023.101755.
- Yamada-Goto N, Sei N, Murai-Takeda A, Azegami T, Sakakibara-Adachi K, Hayashi K, et al. Longitudinal impact of weight change on blood pressure in University students. Hypertens Res. 2025;48(11):2938-2949. doi: 10.1038/s41440-025-02370-1.
- Yano Y. Blood Pressure in Young Adults and Cardiovascular Disease Later in Life. Am J Hypertens. 2021;34(3):250-257. doi: 10.1093/ajh/hpab005.
- Zyriax BC, Dransfeld K, Windler E. Carotid intima-media thickness and cardiovascular risk factors in healthy volunteers. Ultrasound J. 2021;13(1):17. doi: 10.1186/s13089-021-00218-6.
- Publication:
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«World of Medicine and Biology»
Vol. 22 No. 96 (2026)
, с. 30-34
УДК 616.12-008.331.1-056.257-053.6-078:159.9
How to Cite
1.
Bilovol O, Kniazkova I, Derevetska V, Polupan O, Petrukhnov O, Sosonna L, et al. STATUS OF LIPID METABOLISM PARAMETERS, INTIMA-MEDIA COMPLEX THICKNESS, AND PERSONAL ANXIETY IN YOUNG PEOPLE WITH ARTERIAL HYPERTENSION AND OVERWEIGHT. СМБ [Internet]. 2026 May 13 [cited 2026 Jul. 1];22(96):30-4. Available from: https://womab.com.ua/article/view/4064
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