QUALITY OF LIFE IN PATIENTS AFTER WIDESPREAD PERITONITIS OF VARIOUS ETIOLOGIES

Authors:

Abstract:

This study evaluated the impact of three different peritoneal lavage techniques on the quality of life in patients following surgical treatment for widespread peritonitis. A total of 98 patients were examined and allocated into three clinical groups. Quality-of-life outcomes were assessed using the SF-36, GIQLI, and EQ-5D questionnaires at 6 and 12 months post-treatment. The most favorable outcomes across all instruments were observed in the group that used probiotic antiseptics for peritoneal lavage. At one year, the scores for physical, emotional, and social functioning in this group significantly exceeded the corresponding indices in both the enterosorbent and control groups. Probiotic lavage facilitated faster recovery, reduced somatic symptoms, and improved both psycho-emotional status and general health. This positive therapeutic effect remained stable throughout the 12-month follow-up period. Although this method currently remains outside official clinical protocols due to limited evidence base, our findings demonstrate that integrating probiotic peritoneal lavage into comprehensive peritonitis management and long-term post-discharge surveillance is highly justified to improve long-term functional recovery.

Keywords:

peritonitis postoperative period quality of life clinical monitoring

References:

1. Biliaieva OO, Karol IV, Konovalenko SV. Porivnialna kharakterystyka efektyvnosti riznykh metodiv sanatsii cherevnoi porozhnyny pry eksperymentalnomu perytoniti iz zastosuvanniam probiotychnykh antyseptykiv. Klinichna ta profilaktychna medytsyna. 2025; 3 (41): 31–9. DOI: https://doi.org/10.31612/2616-4868.3.2025.04. [in Ukrainian].
2. Guryanov VG, Lyakh YuE, Pariy VD, Korotkyi OV, Chalyi OV, Chalyi KO, et al. Posibnyk z biostatystyky. Analiz rezultativ medychnykh doslidzhen u paketi EZR (R–statistics). Kyiv: News. 2018: 208. [in Ukrainian].
3. Tereshkevych HT. Osnovy bioetyky ta biobezpeky: pidruchnyk. Ternopil: TDMU, 2018, 400 s. [in Ukrainian].
4. Boer KR, van Ruler O, Reitsma JB, Mahler CW, Opmeer BC, Reuland EA, et al. Health related quality of life six months following surgical treatment for secondary peritonitis - Using the EQ-5D questionnaire. Health and Quality of Life Outcomes. 2007. 5: Article 35. https://doi.org/10.1186/1477-7525-5-35
5. Chen C, Wang J, Li J, Zhang W, Ou S. Probiotics, Prebiotics, and Synbiotics for Patients on Dialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Ren Nutr. 2023 Jan;33(1):126-139. doi: 10.1053/j.jrn.2022.04.001.
6. Coccolini F, Tarasconi A, Petracca GL, Perrone G, Giuffrida M, Disisto C, et al. PROPHYlactic Implantation of BIOlogic Mesh in peritonitis (PROPHYBIOM): a prospective multicentric randomized controlled trial. Trials. 2022 Mar 4;23(1):198. doi: 10.1186/s13063-022-06103-4.
7. IDSA. 2024 Guideline Update on Risk Assessment, Diagnostic Imaging, and Microbiological Evaluation of Complicated Intra-Abdominal Infections. Clin Infect Dis. June 2024 https://www.idsociety.org/practice-guideline/intra-abdominal-infections
8. Pan Y, Yang L, Dai B, Lin B, Lin S, Lin E. Effects of Probiotics on Malnutrition and Health-Related Quality of Life in Patients Undergoing Peritoneal Dialysis: A Randomized Controlled Trial. J Ren Nutr. 2021 Mar;31(2):199-205. doi: 10.1053/j.jrn.2020.04.008.
9. Philipp M, Leuchter M, Klar E. Quality of Life after Complex Abdominal Wall Reconstruction. Visc Med. 2020 Aug;36(4):326-332. doi: 10.1159/000505247.
10. Schaaf S, Schwab R, Willms A. Quality of Life After Open Abdominal Treatment With Vacuum-Assisted Wound Closure and Mesh-Mediated Fascial Traction. Mil Med. 2021 Jan 25;186(Suppl 1):452-457. doi: 10.1093/milmed/usaa336.
11. SF-36. Korotke opytuvannia pro stan zdorovia z 36 punktiv. https://www.physiotutors.com/uk/questionnaires/sf-36-rand-36-mos/
12. Siembida N, Sabbagh C, Chal T, Demouron M, Rossi D, Dembinski J, Regimbeau JM. Absence of abdominal drainage after surgery for secondary lower gastrointestinal tract peritonitis is a valid strategy. Surg Endosc. 2022 Oct;36(10):7219-7224. doi: 10.1007/s00464-022-09080-6.
13. Stepanova N. Probiotic interventions in peritoneal dialysis: A review of underlying mechanisms and therapeutic potentials. World J Nephrol. 2024 Dec 25;13(4):98719. doi: 10.5527/wjn.v13.i4.98719.
14. Theodorou A, Jedig A, Manekeller S, Willms A, Pantelis D, Matthaei H, et al. Long Term Outcome After Open Abdomen Treatment: Function and Quality of Life. Front Surg. 2021 Mar 29;8:590245. doi: 10.3389/fsurg.2021.590245.

Publication:

«World of Medicine and Biology» Vol. 22 No. 96 (2026) , с. 35-39
УДК 616.381-002-089-06-036.22

DOI:

https://doi.org/10.26724/2079-8334-2026-2-96-35-39