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Clinical medicine

ROLE OF THE SKIN MICROBIOME IN CHILDREN WITH ATOPIC DERMATITIS AND ITS IMPLICATIONS FOR TARGETED THERAPY

Published 2026-05-13

Authors:

K.V. Vasylyeva
Poltava State Medical University image/svg+xml
https://orcid.org/0000-0001-9116-2774
І.B. Popova
Poltava State Medical University image/svg+xml
V.V. Kryvenko
Poltava State Medical University image/svg+xml
https://orcid.org/0009-0006-3275-3754
K.Ye. Ishcheykin
Poltava State Medical University image/svg+xml
https://orcid.org/0000-0001-7887-0995
Abstract:
Atopic dermatitis in children is a chronic, relapsing inflammatory skin disease frequently associated with alterations of the skin microbiome, which may influence disease severity and treatment outcomes. The aim of this study was to characterize the skin microbial colonization in children with Atopic dermatitis and assess its clinical significance. A total of 128 children with chronic recurrent Atopic dermatitis were examined using bacteriological and mycological analysis of skin lesions. Staphylococcal colonization was identified in 88 % of patients, predominantly Staphylococcus aureus, either as a single pathogen or in association with fungi and other bacteria. Isolated staphylococcal colonization was more common in younger children, whereas mixed microbial infections predominated in older age groups and were associated with more severe disease and reduced responsiveness to conventional therapy. These findings highlight the important role of skin microbiome dysbiosis in the pathogenesis of Atopic dermatitis and support the implementation of personalized therapeutic approaches based on microbial profiling.
Keywords:
atopic dermatitis skin microbiome microbial colonization fungal colonization
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Publication:
«World of Medicine and Biology» Vol. 22 No. 96 (2026) , с. 46-51
УДК 616.5/.516-053.2-085
DOI:
https://doi.org/10.26724/2079-8334-2026-2-96-46-51