IMPACT OF ARMED CONFLICT IN UKRAINE ON MALE REPRODUCTIVE FUNCTION DURING MARTIAL LAW
Clinical medicine

IMPACT OF ARMED CONFLICT IN UKRAINE ON MALE REPRODUCTIVE FUNCTION DURING MARTIAL LAW

Published 2026-05-13

Authors:

L.L. Vorontsova
Zaporizhzhia State Medical and Pharmaceutical University image/svg+xml
https://orcid.org/0000-0003-4115-2951
V.A. Kovalenko
Zaporizhzhia State Medical and Pharmaceutical University image/svg+xml
https://orcid.org/0000-0003-2385-8547
O.S. Kozachuk
Zaporizhzhia State Medical and Pharmaceutical University image/svg+xml
https://orcid.org/0000-0001-6088-6665

Abstract:
Given that debates persist within the scientific community regarding the magnitude of the impact of stressors on infertility, this study aimed to evaluate the influence of psycho-emotional state under conditions of military aggression on male reproductive function parameters. A retrospective analysis of semen parameters and psycho-emotional status was conducted in 895 clinically healthy men aged 21–42 years over the 2016–2025 period. Anxiety and depression were evaluated using the GAD-7 and PHQ-9 scales, respectively. Semen analysis was performed in strict accordance with WHO recommendations. Beginning in 2022, a statistically significant increase in anxiety levels and the emergence of mild depressive symptoms were observed among the evaluated men. Concurrently, a marked decline was noted in sperm concentration, motility, and the percentage of morphologically normal forms, alongside an accumulation of abnormal and immotile spermatozoa. Over the 2023–2025 period, key semen parameters deviated beyond the acceptable reference intervals. Prolonged psycho-emotional stress under war conditions is strongly associated with the deterioration of semen quality and reduced male fertility. These findings underscore the critical need for further investigation and the development of targeted interventions aimed at preserving male reproductive health.
Keywords:
stress fertility reproduction endocrine disorders demographic situation
References:
  1. Chepurko H. Vyklyky y zahrozy demohrafichniy stiykosti Ukrayiny pid chas viyny. Sotsiolohichni studiyi. 2025 hrud. 1(26); 58–72. https://doi.org/10.29 038/2306-3971-2025-01-43-43.
  2. Agarwal A, Baskaran S, Parekh N, Cho CL, Henkel R, Vij S, et al. Male infertility. Lancet. 2021 Jan 23;397(10271):319-333. doi: 10.1016/S0140-6736(20)32667-2.
  3. Björndahl L, Kirkman Brown J; other Editorial Board Members of the WHO Laboratory Manual for the Examination and Processing of Human Semen. The sixth edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen: ensuring quality and standardization in basic examination of human ejaculates. Fertil Steril. 2022 Feb;117(2):246-251. doi: 10.1016/j.fertnstert.2021.12.012.
  4. Charlson F, van Ommeren M, Flaxman A, Cornett J, Whiteford H, Saxena S. New WHO prevalence estimates of mental disorders in conflict settings: a systematic review and meta-analysis. Lancet. 2019 Jul 20;394(10194):240-248. doi: 10.1016/S0140-6736(19)30934-1.
  5. Chung E, Atmoko W, Saleh R, Shah R, Agarwal A. Sixth edition of the World Health Organization laboratory manual of semen analysis: Updates and essential take away for busy clinicians. Arab J Urol. 2023 Dec 25;22(2):71-74. doi: 10.1080/20905998.2023.2298048.
  6. Esteves SC. The WHO 2025 Guideline for the Prevention, Diagnosis and Treatment of Infertility: A Comprehensive Review with Focus on Male Reproductive Health. Int Braz J Urol. 2026 May-Jun;52(3):e20260121. doi: 10.1590/S1677-5538.IBJU.2026.0121.
  7. Gunes S, Esteves SC. Role of genetics and epigenetics in male infertility. Andrologia. 2021 Feb;53(1):e13586. doi: 10.1111/and.13586.
  8. Hussain T, Kandeel M, Metwally E, Murtaza G, Kalhoro DH, Yin Y, et al. Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight. Front Endocrinol (Lausanne). 2023 Feb 13;14:1070692. doi: 10.3389/fendo.2023.1070692.
  9. Kaltsas A, Papaharitou S, Dimitriadis F, Chrisofos M, Sofikitis N. Psychological Stress and Male Infertility: Oxidative Stress as the Common Downstream Pathway. Biomedicines. 2026 Jan 23;14(2):259. doi: 10.3390/biomedicines14020259.
  10. Karunyam BV, Abdul Karim AK, Naina Mohamed I, Ugusman A, Mohamed WMY, Faizal AM, et al. Infertility and cortisol: a systematic review. Front Endocrinol (Lausanne). 2023 Jun 29;14:1147306. doi: 10.3389/fendo.2023.1147306.
  11. Militello R, Traini G, Pinto G, Gamberi T, Luti S, Marchiani S, et al. Association Among Sperm Adiponectin, DNA Fragmentation, Oxidative Stress and Metabolites in Male Infertility. Antioxidants (Basel). 2025 Nov 27;14(12):1427. doi: 10.3390/antiox14121427.
  12. Smith SM, Vale WW. The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialogues Clin Neurosci. 2006;8(4):383-95. doi: 10.31887/DCNS.2006.8.4/ssmith.
  13. Spitzer RL, Kroenke K, Williams JB, Löwe B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med. 2006 May 22;166(10):1092-7. doi: 10.1001/archinte.166.10.1092.
  14. Spitzer TL, Trussell JC, Coward RM, Hansen KR, Barnhart KT, Cedars MI, et al. Biomarkers of Stress and Male Fertility. Reprod Sci. 2022 Apr;29(4):1262-1270. doi: 10.1007/s43032-022-00853-x.
  15. Utigalieva E, Morozov A, Shoshany O, Suvorov A, Taratkin M, Manfredi C, et al. EAU-YAU Sexual and Reproductive Health Working Group. A systematic review and meta-analysis of the placebo effect on both semen quality and male infertility. Minerva Urol Nephrol. 2024 Aug;76(4):423-435. doi: 10.23736/S2724-6051.24.05559-9.
  16. Whirledge S, Cidlowski JA. A role for glucocorticoids in stress-impaired reproduction: beyond the hypothalamus and pituitary. Endocrinology. 2013 Dec;154(12):4450-68. doi: 10.1210/en.2013-1652.
  17. WHO laboratory manual for the examination and processing of human semen, sixth edition. Geneva: World Health Organization; 2021.
Publication:
«World of Medicine and Biology» Vol. 22 No. 96 (2026) , с. 51-56
УДК 616.697/.699-074(477)"364"