PROGNOSTIC ASSESSMENT OF TISSUE PERFUSION IN WOUNDED PATIENTS WITH COMBAT-RELATED COMBINED COLD THERMOMECHANICAL INJURY USING DOPPLER ULTRASONOGRAPHY AND THERMOMETRY
Clinical medicine

PROGNOSTIC ASSESSMENT OF TISSUE PERFUSION IN WOUNDED PATIENTS WITH COMBAT-RELATED COMBINED COLD THERMOMECHANICAL INJURY USING DOPPLER ULTRASONOGRAPHY AND THERMOMETRY

Published 2026-05-13

Authors:

S.O. Korol
Ukrainian Military Medical Academy image/svg+xml
https://orcid.org/0000-0002-1036-0355
A.L. Chelishvili
Poltava State Medical University image/svg+xml
I.P. Palii
Ukrainian Military Medical Academy image/svg+xml
https://orcid.org/0000-0001-8361-1592
M.A. Denysiuk
Ukrainian Military Medical Academy image/svg+xml
https://orcid.org/0009-0008-4864-7109

Abstract:
Combat extremity injuries combined with systemic hypothermia and local cold-induced tissue damage are associated with a high risk of regional ischemia and secondary necrosis, and early objective assessment of tissue viability remains a major clinical challenge. This study included 213 wounded service members with firearm fractures of the extremities accompanied by general hypothermia and local cold injury, in whom regional perfusion was evaluated using venous ultrasound assessment and infrared thermography. Severe impairment of venous outflow was strongly associated with the development of secondary necrosis and was accompanied by a more than threefold increase in relative risk. Venous hemodynamic parameters demonstrated high predictive accuracy and exceeded the prognostic value of temperature asymmetry. The combined use of ultrasound assessment and thermographic analysis improved risk stratification and enabled early identification of critically impaired tissue perfusion. These findings confirm the leading role of venous microcirculatory dysfunction in the progression of ischemic tissue damage and support the use of integrated perfusion assessment in early clinical decision-making.
Keywords:
combat surgical trauma frostbite firearm fracture osteosynthesis polytrauma
References:
  1. Bruen KJ, Ballard JR, Morris SE, Cochran A, Edelman LS, Saffle JR. Reduction of the incidence of amputation in frostbite injury with thrombolytic therapy. Journal of Vascular Surgery. 2020. 72(1). 220-226. doi: 10.1016/j.jvs.2019.09.050.
  2. Cannon JW. Hemorrhagic shock and microcirculatory dysfunction. Critical Care. 2021. 25(1). 101. doi: 10.1186/s13054-021-03540-5.
  3. Cauchy E, Davis CB, Pasquier M, Meyer EF, Hackett PH. A new proposal for management of severe frostbite in extreme environments. Scandinavian Journal of Trauma Resuscitation and Emergency Medicine. 2021. 29(1). 123. doi: 10.1186/s13049-021-00917-5.
  4. Clasper JC, Ramasamy A. Traumatic ischemia and reperfusion injury in combat trauma. Journal of the Royal Army Medical Corps. 2020. 166(2). 90-95. doi: 10.1136/jramc-2019-001302.
  5. Davis CB, Cauchy E, Pasquier M. Contemporary management of frostbite injury. International Journal of Environmental Research and Public Health. 2023. 20(4). 3157. doi: 10.3390/ijerph20043157.
  6. Handford C, Buxton P, Russell K, Imray CHE, McIntosh SE, Freer L. Frostbite a practical approach to hospital management. Emergency Medicine Journal. 2020. 37(9). 555-561. doi: 10.1136/emermed-2019-208798.
  7. Imray C, Grieve A, Dhillon S. Cold damage to the extremities frostbite and non freezing cold injuries. Postgraduate Medical Journal. 2021. 97(1147). 420-427. doi: 10.1136/postgradmedj-2020-139097.
  8. Lahiri BB, Bagavathiappan S, Jayakumar T, Philip J. Medical applications of infrared thermography a review. Infrared Physics and Technology. 2020. 110. 103447. doi: 10.1016/j.infrared.2020.103447.
  9. McIntosh SE, Opacic M, Freer L, Auerbach PS, Rodway GW, Grissom CK, et al. Wilderness Medical Society clinical practice guidelines for the prevention and treatment of frostbite 2024 update. Wilderness and Environmental Medicine. 2024. 35(1). 12-34. doi: 10.1016/j.wem.2023.10.006.
  10. Mills JL, Conte MS, Armstrong DG, Pomposelli FB, Schanzer A, Sidawy AN, et al. The Society for Vascular Surgery lower extremity threatened limb classification system risk stratification based on wound ischemia and foot infection. Journal of Vascular Surgery. 2021. 73(1 Suppl). 30S-40S. doi: 10.1016/j.jvs.2020.08.121.
  11. Pasquier M, Zafren K, Brugger H, Darocha T, Blancher M, Brown DJA. Frostbite management current concepts and future perspectives. The Lancet. 2022. 400(10348). 118-130. doi: 10.1016/S0140-6736(22)01121-9.
  12. Perkins ZB, Yet B, Marsh W, Tai NRM, Brohi K. Early identification of limb ischemia in trauma patients using Doppler ultrasound. Injury. 2020. 51(9). 1987-1994. doi: 10.1016/j.injury.2020.06.021.
  13. Ring EFJ, Ammer K. Infrared thermal imaging in medicine. Physiological Measurement. 2021. 42(3). 034001. doi: 10.1088/1361-6579/abd3fd.
  14. Sheridan RL. Frostbite and cold injury pathophysiology and clinical implications. Journal of Trauma and Acute Care Surgery. 2021. 91(2). e45-e52. doi: 10.1097/TA.0000000000003261.
  15. Shina A, Lipsky AM, Gausche-Hill M, et al. Diagnostic utility of Doppler ultrasonography in extremity vascular trauma. Journal of Trauma and Acute Care Surgery. 2022. 93(4). 512–519. doi: 10.1097/TA.0000000000003691.
  16. Wibbenmeyer L, Amelon M, Morgan L, Robinson BK, Kealey GP, Lewis RW. Infrared thermography in evaluation of tissue perfusion. Burns. 2020. 46(6). 1365-1373. doi: 10.1016/j.burns.2020.02.022.
Publication:
«World of Medicine and Biology» Vol. 22 No. 96 (2026) , с. 71-76
УДК 616–001.18/.19+616.71–001.5]–089–057.36:355