CYTOKINE PROFILE IN INTESTINAL PARASITIC INFECTIONS AND THE EFFECTIVENESS OF PROBIOTICS IN COMPLEX TREATMENT

Authors:

Abstract:

Intestinal parasitic infections caused by Giardia duodenalis, Ascaris lumbricoides, and Enterobius vermicularis remain clinically relevant due to their association with gastrointestinal symptoms, intestinal dysbiosis, and immune dysregulation. This study analyzed the cytokine and T-cell immune profiles in students aged 17–24 years with giardiasis, ascariasis, enterobiasis, and mixed parasitic infections, and evaluated the effectiveness of probiotic supplementation in complex therapy. Giardiasis was associated with reduced CD3+, and increased serum levels of interleukin-4, interleukin-6, and interleukin-10. Ascariasis was characterized by a pronounced increase in interleukin-6, whereas enterobiasis showed elevated interleukin-4 and signs of inflammatory activation. The addition of probiotics improved treatment effectiveness in giardiasis and ascariasis and may contribute to restoration of intestinal microbiocenosis and modulation of cytokine responses. A comprehensive approach combining antiparasitic therapy, dysbiosis correction, and immunological monitoring may improve treatment outcomes.

Keywords:

intestinal parasitosis giardiasis ascariasis cytokines probiotics

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Publication:

«World of Medicine and Biology» Vol. 22 No. 96 (2026) , с. 81-86
УДК 616.995.1:616-097:615.37

DOI:

https://doi.org/10.26724/2079-8334-2026-2-96-81-86