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Clinical medicine

CLINICAL MANIFESTATIONS OF NECROBIOSIS LIPOIDICA AND CONTEMPORARY TREATMENT STRATEGIES

Published 2026-06-30

Authors:

Mahmudov F.R.
Azerbaijan Medical University image/svg+xml
https://orcid.org/0009-0001-0855-8610
Madatli A.N.
Azerbaijan Medical University image/svg+xml
https://orcid.org/0009-0000-0213-0501
Nasibov A.A.
Azerbaijan Medical University image/svg+xml
https://orcid.org/0009-0009-3502-4727
Haciyeva X.A.
Azerbaijan Medical University image/svg+xml
https://orcid.org/0009-0003-0707-1039
Abstract:
Necrobiosis lipoidica is considered one of the diabetes-associated cutaneous manifestations of diabetes mellitus. The disease is characterized by granulomatous inflammation with pathological signs of collagen necrobiosis and inflammation of the dermis. The purpose of the study was to examine patients in order to collect data on the epidemiology of necrobiosis lipoidica in Azerbaijan, to visually assess changes in the appearance of necrobiosis lipoidica lesions, and to compare lipid-profile, carbohydrate-metabolism and coagulation-profile parameters before and after the proposed treatment. Various clinical forms of necrobiosis lipoidica, its association with diabetes mellitus, disease duration and concomitant diseases were assessed; histomorphological examination of biopsy specimens was performed. A drug based on sweet clover was included in the treatment regimen. Before and after treatment, necrobiosis lipoidica lesions were objectively examined, and trends in lipid-profile, carbohydrate-metabolism and coagulation-profile parameters were compared. The use of a drug based on sweet clover in combination with traditional treatment helped to reduce the diameter of the lesion, a change in lesion color to pale yellow or skin-colored, disappearance of inflammation of the peripheral rim, regression of subjective complaints, and favorable changes in carbohydrate metabolism, lipid metabolism and coagulation-profile parameters.
Keywords:
necrobiosis lipoidica a drug based on sweet clover cutaneous lesions carbohydrate metabolism lipid profile coagulation profile
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Publication:
«World of Medicine and Biology» Vol. 22 No. 96 (2026) , с. 87-92
УДК 616.5-002.54-003.826-036.12
DOI:
https://doi.org/10.26724/2079-8334-2026-2-96-87-92