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Clinical medicine

CORRELATIONS BETWEEN HEMOGLOBIN LEVEL AND DISEASE ACTIVITY PARAMETERS IN JUVENILE IDIOPATHIC ARTHRITIS

Published 2026-06-30

Authors:

Salamzade G.Z.
Azerbaijan Medical University image/svg+xml
https://orcid.org/0009-0001-6986-913X
Sultanova N.H.
Azerbaijan Medical University image/svg+xml
https://orcid.org/0000-0003-4788-466X
Mammadova S.N.
Azerbaijan Medical University image/svg+xml
https://orcid.org/0009-0004-3789-2871
Abstract:

Anemia is a frequent extra-articular manifestation of juvenile idiopathic arthritis and may reflect persistent inflammatory activity. This study evaluated associations between hemoglobin level and clinical and laboratory indicators of disease activity in children with juvenile idiopathic arthritis. The study included 80 patients aged 2–18 years and 20 apparently healthy children. Patients with juvenile idiopathic arthritis had higher leukocyte, platelet, erythrocyte sedimentation rate, and C-reactive protein values and lower hemoglobin levels than the control group. Hemoglobin showed statistically significant negative correlations with erythrocyte sedimentation rate, C-reactive protein, platelet count, leukocyte count, neutrophil count, overall disease activity score, and involvement of several upper limb joints. These findings indicate that decreasing hemoglobin level may serve as an additional marker of inflammatory burden and more aggressive joint involvement in juvenile idiopathic arthritis, particularly in patients with polyarticular and systemic patterns of disease.

Keywords:
pediatric rheumatology inflammatory anemia disease activity erythrocyte sedimentation rate C-reactive protein joint involvement
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Publication:
«World of Medicine and Biology» Vol. 22 No. 96 (2026), pp. 122-126
UDC 616.72-002.77-053.2:616.155.194-07
DOI:
https://doi.org/10.26724/2079-8334-2026-2-96-122-126