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Clinical medicine

ASSESSMENT OF BLOOD COAGULATION SYSTEM STATUS IN PATIENTS WITH SENSORINEURAL HEARING IMPAIRMENTS WHO HAVE RECOVERED FROM COVID-19

Published 2026-06-30

Authors:

Shydlovska T.A.
Institute of Otolaryngology named after Prof. A.I. Kolomiychenko of the National Academy of Medical Sciences of Ukraine image/svg+xml
https://orcid.org/0000-0002-7894-359X
Bezeha M.I.
Aklan State University image/svg+xml
https://orcid.org/0000-0002-1250-1190
Burlaka Yu.B.
Institute of Otolaryngology named after Prof. A.I. Kolomiychenko of the National Academy of Medical Sciences of Ukraine image/svg+xml
https://orcid.org/0000-0003-0821-4268
Voroshilova N.M.
Institute of Otolaryngology named after Prof. A.I. Kolomiychenko of the National Academy of Medical Sciences of Ukraine image/svg+xml
https://orcid.org/0000-0002-7174-2090
Ver'ovka S.V.
Institute of Otolaryngology named after Prof. A.I. Kolomiychenko of the National Academy of Medical Sciences of Ukraine image/svg+xml
https://orcid.org/0000-0002-3578-7996
Abstract:
COVID-19 is a systemic disease that affects various body systems, including the auditory system and the hemostatic system. Changes in platelet-vascular, coagulation, and fibrinolytic components of hemostasis were studied in 32 patients with sensorineural hearing impairments who had recovered from COVID-19 and 20 healthy individuals with normal hearing. Normalization of fibrinogen and ecarin time was established. An increase in soluble fibrin concentration was detected against the background of decreased D-dimer levels. This indicates the activation of the blood coagulation system and the inability of fibrinolysis to hydrolyze fibrin clots, which is indirectly confirmed by increased levels of RFMC. A decrease in protein C content was established, indicating intravascular thrombin generation, as a result of which there is an increase in prothrombin-1 and soluble fibrin concentration. Prolongation of activated partial thromboplastin time and prothrombin time against the background of changes in the aforementioned parameters is a manifestation of chronic consumptive coagulopathy. The absence of normalization of hemostasis parameters in patients who have recovered from COVID-19 is an unfavorable prognostic sign.
Keywords:
COVID-19 post-COVID syndrome sensorineural hearing loss hemostasis soluble fibrin chronic coagulopathy
References:
  1. Komisarenko S, Korda M, Vari Sh. Vyznachennia zahrozy vnutrishnosudynnoho tromboutvorennia u patsiientiv yaki perekhvorily na COVID-19. Metodychni rekomendatsii, 2024. 40 s. [in Ukrainian].
  2. Markov Yu, Markova I, Horiainova N, Kuiavovych B. Hematolohichni porushennia yak uskladnennia COVID-19. Medytsyna nevidkladnykh staniv. 2023;19(6):419–426. DOI: http://dx.doi.org/10.22141/2224-0586.19.6.2023.1622. [in Ukrainian].
  3. Shydlovska T, Shydlovska T, Kozak M, Ovsianyk K, Bezeha M. Pokaznyky reoentsefalohrafii u osib, yaki perenesly postkovidnyi syndrom. Dovkillia ta zdorovia. 2025;2:55–61. DOI: 10.32402/dovkil2025.02.055. [in Ukrainian].
  4. Agbuduwe C, Basu S. Haematological manifestations of COVID-19: from cytopenia to coagulopathy. Eur. J. Haematol. 2020;105(5):540–546. DOI: 10.1111/ ejh.13491.
  5. Bikdeli B, Madhavan M, Jimeniez D. COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy and follow-up. J Am Coll Cardiol. 2020;75:2950–2973. DOI: 10.1016/j.jacc.2020.04.031.
  6. Connors JM, Levy JH. COVID-19 and its implications for thrombosis and anticoagulation. Blood. 2020;135(23):2033–2040. DOI: 10.1182/blood.2020006000.
  7. Favaloro E, Lippi G. Recommendations for Minimal Laboratory Testing Panels in Patients With COVID-19: Potential for Prognostic Monitoring. Semin. Thromb. Hemost. 2020;46:379–382. DOI: 10.1055/s-0040-1709498.
  8. Klok F, Kruipb M, van der Meerc N. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020;191:145–147. DOI: 10.1016/j.thromres.2020.04.013.
  9. Munro K, Uus K, Almufarrij I, Chaudhuri N, Yioe V. Persistent self-reported changes in hearing and tinnitus in posthospitalisation COVID-19 cases. Int J Audiol. 2020;59(12):889–890. DOI: 10.1080/14992027.2020.1798519.
  10. Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J. Thromb. Haemost. 2020;18:844–847. DOI: 10.1111/jth.14820.
  11. Thachil J, Tang N, Gando S. ISTH interim guidance on recognition and management of coagulopathy in COVID-19. J. Thromb. Haemost. 2020;18:1023–1026. DOI: 10.1111/jth.14810.
  12. Vari S. COVID-19 infection: disease mechanism, vascular dysfunction, immune responses, markers, multiorgan failure, treatments, and vaccination. Ukr Biochem J. 2020;92(3):6–21. DOI: 10.15407/ubj92.03.006.
  13. Zermatten M, Fraga M, Moradpour D. Haemostatic alterations in cirrhotic patients: from primary haemostasis to fibrinolysis. Hepatology. 2020;71:2135–2148. DOI: 10.1002/hep.31201.
Publication:
«World of Medicine and Biology» Vol. 22 No. 96 (2026) , с. 140-144
УДК 612.115-06:616.28-008.1-02:616.98:578.834]-047.44
DOI:
https://doi.org/10.26724/2079-8334-2026-2-96-140-144