DYNAMICS OF MORPHOLOGICAL CHANGES IN THE GLOMERULAR ZONE OF THE ADRENAL CORTEX IN RATS DURING THE EARLY STAGES OF THE EXPERIMENT FOLLOWING ADMINISTRATION OF A COMPLEX OF DIETARY SUPPLEMENTS

Authors:

Abstract:

This article presents the results of an experimental study of changes in the glomerular zone of the adrenal cortex under the influence of a complex of food additives (monosodium glutamate, sodium nitrite, Ponceau 4R). The relevance of this work stems from the prevalence of endocrine pathology and the influence of exogenous factors on the hypothalamic-pituitary-adrenal axis. The study was conducted on 84 white rats using morphological and morphometric methods. It was established that the glomerular zone undergoes pronounced destructive-degenerative changes: cellular disorganization, loss of lipid inclusions, nuclear pyknosis, and the formation of apoptotic bodies. The detected changes indicate impaired mineralocorticoid synthesis and, consequently, disturbances in water-electrolyte balance. The results obtained highlight the sensitivity of the glomerular zone to dietary xenobiotics and emphasize the importance of dietary factors in maintaining endocrine homeostasis, laying the groundwork for preventive strategies in clinical practice.

Keywords:

rats morphology adrenal glands glomerular zone morphometry microscopic changes

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Publication:

«World of Medicine and Biology» Vol. 22 No. 96 (2026) , с. 150-154
УДК 611.45-031:613.29]-092.9

DOI:

https://doi.org/10.26724/2079-8334-2026-2-96-150-154