EFFECT OF A THERAPEUTIC AND PREVENTIVE COMPLEX ON THE BIOCHEMICAL INDICATORS OF RAT BLOOD SERUM UNDER CONDITIONS OF A CARIES-INDUCING DIET AND DIETARY VITAMIN D DEFICIENCY ON THE BACKGROUND AND DESTRUCTION OF JAW BONE TISSUE

Authors:

Abstract:

This study was devoted to assessing the effect of the proposed therapeutic and prophylactic complex on the biochemical parameters of rat serum under conditions of a cariogenic diet and dietary vitamin D deficiency against a background of jawbone destruction. Experimental studies were conducted on 30 four-month-old male Wistar rats. During the experiment, the animals were divided into three groups of 10 rats each: Group 1 – intact animals; Group 2 – trauma to the lower jaw region in the projection of the molar roots and modeling of dietary vitamin D deficiency against a background of a high-sucrose cariogenic diet; Group 3 – pathology model and administration of the therapeutic and prophylactic complex. Modeling of the pathological condition resulted in a 27.8 % decrease in total calcium concentration, a 19.8 % decrease in inorganic phosphorus concentration, a 14.3 % decrease in total vitamin D level, a 1.5-fold reduction in magnesium concentration, and a 1.4-fold decrease in osteocalcin level, accompanied by a 1.4-fold increase in parathyroid hormone concentration. Administration of the proposed therapeutic and prophylactic complex contributed to the correction of the identified disorders and normalization of the studied parameters toward the values observed in intact animals.

Keywords:

bone destruction rats vitamin D deficiency dental caries blood serum experiment

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Publication:

«World of Medicine and Biology» Vol. 22 No. 96 (2026) , с. 160-165

DOI:

https://doi.org/10.26724/2079-8334-2026-2-96-160-165