ALARMINS TSLP, IL-25, IL-33 AS A TARGET FOR THE DIAGNOSIS AND TREATMENT OF CHRONIC RECURRENT HERPETIC STOMATITIS

Authors:

Abstract:

Chronic recurrent herpetic stomatitis is one of the most prevalent viral diseases of the oral mucosa, with incompletely understood pathogenesis. This review systematizes current evidence on the role of epithelial alarmins – thymic stromal lymphopoietin, interleukin-33, and interleukin-25 – in the pathogenesis of chronic reccurent herpetic stomatitis. A concept of a self-perpetuating alarmin-driven pathogenetic cycle is proposed, along with immunological rationale for optimizing CRHS treatment by combining antiviral therapy with zinc supplementation and diode laser photobiomodulation.

Keywords:

herpes simplex virus infection herpetic stomatitis interleukin-33 interleukin-25 alarmins thymic stromal lymphopoietin

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Publication:

«World of Medicine and Biology» Vol. 22 No. 96 (2026) , с. 211-220
УДК 616.31-002:616.523-07-08

DOI:

https://doi.org/10.26724/2079-8334-2026-2-96-211-220