NEUROVISCERAL DYSREGULATION AND SYSTEMIC AUTONOMIC DYSFUNCTION IN ALCOHOL DEPENDENCE

Authors:

Abstract:

The purpose of the study was to systematize modern data concerning the autonomic nervous system involvement in alcohol dependence and propose a multi-level integrative model of autonomic dysregulation. An analytical review of the literature was conducted using PubMed, Google Scholar, Web of Science and Scopus databases. Contemporary clinical and experimental studies were analyzed alongside fundamental research in neurophysiology, neuroendocrine, and neuroimmune regulation. A systems-based and pathophysiological approach was applied. The findings showed systemic autonomic dysfunction formation with multisystem involvement, including cardiovascular, gastrointestinal, respiratory, thermoregulatory, urogenital, metabolic-endocrine and immune systems as a result of chronic alcohol exposure. These alterations occur across multiple hierarchical levels of autonomic nervous system organization and are associated with impaired integration of neurovegetative, neuroendocrine, and immune regulatory pathways. The proposed model conceptualizes autonomic dysfunction as a systemic process and provides a framework for the development of targeted diagnostic, prognostic, and therapeutic strategies in alcohol dependence. Authors conclude that chronic alcohol exposure is associated with systemic autonomic dysfunction which results in regulatory systems generalized disruption. Autonomic dysfunction follows a continuum from subclinical regulatory disturbances to overt organ manifestations, determining disease progression. The proposed integrative model provides a conceptual basis for personalized diagnostic and therapeutic approaches in alcohol dependence.

Keywords:

alcohol dependence autonomic nervous system autonomic dysfunction central autonomic network neurovisceral integration multisystem dysregulation pathophysiological mechanisms

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Publication:

«World of Medicine and Biology» Vol. 22 No. 96 (2026) , с. 248-255
УДК 616.89-008.441.13-036.66

DOI:

https://doi.org/10.26724/2079-8334-2026-2-96-248-255