MORPHOLOGICAL CHARACTERISTICS OF STRUCTURAL COMPONENTS OF RAT KIDNEYS UNDER THE ACTION OF FOOD SUPPLEMENTS

Authors:

Abstract:

The study provides a comprehensive, in-depth, and systematic analysis of the structural and functional characteristics of the macro- and microscopic organization of rat kidneys under normal conditions, and establishes in detail the pathogenetic mechanisms underlying structural remodeling of excretory system tissues under the toxic effects of the synthetic food dye Ponceau 4R. To fully achieve this aim, the study addresses a complex of interrelated tasks, beginning with a fundamental description of the histotopographic organisation of the intact kidney of the laboratory rat as a reference experimental model. This stage involves a detailed examination of the unilobar architectonics of the organ, the spatial distribution of superficial, midcortical and juxtamedullary nephrons, the relative proportions of their loops, and the microscopic organisation of the renal corpuscle and of the system of convoluted and collecting tubules. It also includes a thorough investigation of the cytotoxic and nephrotoxic effects of the food additive Ponceau 4R at the cellular and tissue levels. This encompasses the elucidation of the molecular mechanisms of damage to the components of the renal filtration barrier, the mechanisms of induction of oxidative stress in renal tissue, the initiation of apoptosis of the epithelial cells of the proximal tubules, and the aggregation of serum albumin under the action of dye metabolites. The final aspect is the formation of an integrated morphological picture of the pathological changes and haemodynamic disturbances in the kidneys, which will make it possible to provide scientific justification of the biological risks of consumption of this food additive and to create a sound fundamental theoretical basis for understanding the pathogenesis of alimentary nephropathy and for the further development of strategies for morphological correction of the disturbances detected.

Keywords:

kidneys rats food additives Ponceau 4R nephrotoxicity excretory system organs oxidative stress histological analysis renal corpuscle tubular epithelium

References:

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Publication:

«World of Medicine and Biology» Vol. 22 No. 96 (2026) , с. 264-271
УДК 611.61:613.29]-092.9(048.8)

DOI:

https://doi.org/10.26724/2079-8334-2026-2-96-264-271