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Clinical medicine

CHANGES IN THE ACTIVITY OF NITRIC OXIDE PRODUCTION AND THE CONTENT OF CORTISOL IN THE BLOOD OF PATIENTS IN THE ACUTE PERIOD OF MYOCARDIAL INFARCTION

Published 2026-09-30

Authors:

Honchar O.O.
Poltava State Medical University image/svg+xml
https://orcid.org/0000-0003-4779-2773
Skrypnyk I.M.
Poltava State Medical University image/svg+xml
https://orcid.org/0000-0002-3426-3429
Akimov O.Y.
Poltava State Medical University image/svg+xml
https://orcid.org/0000-0002-4958-3695
Sorokina S.I.
Poltava State Medical University image/svg+xml
https://orcid.org/0000-0001-8515-4938
Abstract:
Current research is devoted to studying the role of nitric oxide and NO synthase in ensuring the functioning of the cardiovascular system. The purpose of the study was to examine changes in the activity of different isoforms of NO synthase (inducible, endothelial and neuronal), the content of nitrites, peroxynitrites and cortisol in the blood of patients in the acute period of myocardial infarction without Q wave and Q-infarction. The development of Q-wave infarction is accompanied by an increase in the production of nitric oxide in the blood from the L-arginine-dependent pathway of its formation, which leads to the accumulation of active nitrogen forms, while in myocardial infarction without a Q wave there is no increase in the production of nitric oxide in the blood from the L-arginine-dependent pathway of its formation, however, the concentration of active nitrogen forms in the blood increases more markedly.
Keywords:
Q-wave infarction non-Q-wave infarction nitric oxide cortisol NO synthase
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Publication:
«World of Medicine and Biology» Vol. 22 No. 97 (2026), pp. 23-27
UDC 616.127-005.8:616.15-071-085
DOI:
https://doi.org/10.26724/2079-8334-2026-3-97-23-27