CORRECTION OF MICROBIAL CONTAMINATION PARAMETERS AND LOCAL NONSPECIFIC IMMUNE STATUS IN THE ORAL FLUID OF PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS, OSTEOPENIA, AND OSTEOPOROSIS USING A THERAPEUTIC AND PROPHYLACTIC COMPLEX

Authors:

Abstract:

Changes in oral fluid urease and lysozyme activities were assessed in patients with chronic generalised periodontitis associated with osteopenia and osteoporosis. Thirty-five adults aged 25–55 years were examined: 10 healthy individuals, 12 comparison-group patients receiving standard therapy, and 13 main-group patients receiving an adjunctive therapeutic and prophylactic complex. Assessments were performed before treatment and at 3 and 8 months, 1.5 years, and 2 years. In the main group, urease activity decreased from 0.181±0.010 to 0.055±0.003 μkat/L at 8 months and was 0.070±0.004 μkat/L at 2 years. Lysozyme activity increased from 68±3 to 165±12 U/L at 1.5 years and was 152±11 U/L at 2 years. The comparison group showed no sustained urease reduction and less pronounced lysozyme changes. The findings describe favourable biochemical changes with the complex.

Keywords:

chronic generalised periodontitis osteopenia osteoporosis oral fluid urease lysozyme therapeutic and prophylactic complex

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Publication:

«World of Medicine and Biology» Vol. 22 No. 97 (2026), pp. 38-43
UDC [616-053.88+616.71-007.234]:616.31-08-039.71

DOI:

https://doi.org/10.26724/2079-8334-2026-3-97-38-43