DIAGNOSTIC VALUE OF PRESEPSIN AND INTERLEUKIN-33 IN BACTERIAL INFECTIONS IN TERM NEONATES

Authors:

Abstract:

This study evaluated the diagnostic value of presepsin and interleukin-33 (IL-33) in term neonates with bacterial infections. The prospective study included 36 term neonates with neonatal pneumonia or sepsis and 13 healthy controls. Serum C-reactive protein, procalcitonin, presepsin, IL-33, and lactate were assessed. Infected neonates had significantly higher concentrations of all biomarkers than controls (p<0.05), with the greatest increases observed for presepsin and IL-33. ROC analysis demonstrated excellent diagnostic performance for presepsin (AUC=0.971), CRP (AUC=0.971), lactate (AUC=0.965), and IL-33 (AUC=0.961), whereas procalcitonin showed lower accuracy (AUC=0.789). Presepsin and IL-33 demonstrated 94.1 % sensitivity and 100 % specificity. A strong positive correlation was found between presepsin and IL-33. These findings indicate that presepsin and IL-33 are highly informative biomarkers whose combined assessment with conventional laboratory markers may improve early diagnosis and clinical management of bacterial infections in term neonates.

Keywords:

term neonates bacterial infection neonatal sepsis neonatal pneumonia presepsin interleukin-33 biomarkers C-reactive protein procalcitonin

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Publication:

«World of Medicine and Biology» Vol. 22 No. 97 (2026), pp. 51-57
UDC 616-053.31-022.7-074

DOI:

https://doi.org/10.26724/2079-8334-2026-3-97-51-57