CORRECTION OF BIOCHEMICAL PARAMETERS IN THE JAWS OF RATS USING A THERAPEUTIC AND PROPHYLACTIC COMPLEX UNDER CONDITIONS OF A CARIOGENIC DIET AND DIETARY VITAMIN D DEFICIENCY ACCOMPANIED BY JAWBONE DESTRUCTION

Authors:

Abstract:

This study assessed the effect of the proposed therapeutic and prophylactic complex on biochemical markers of rat jawbone tissue under conditions of a cariogenic diet and dietary vitamin D deficiency. Experimental studies were conducted on 30 four-month-old male Wistar rats. The animals were divided into three groups of ten: Group 1, intact animals; Group 2, injury to the mandibular region corresponding to the molar roots and modelling of dietary vitamin D deficiency against a background of a high-sucrose cariogenic diet; and Group 3, the pathology model with administration of the therapeutic and prophylactic complex. Markers of bone resorption and formation, namely acid and alkaline phosphatase activities, were determined in alveolar bone homogenates, and mineralisation was assessed by calcium content. The mineralisation index was calculated as the ratio of alkaline to acid phosphatase activity. Modelling of the pathological condition resulted in a 7.5 % increase in the degree of alveolar atrophy, a 34 % increase in acid phosphatase activity, a 31.12 % decrease in alkaline phosphatase activity and a 13.16 % decrease in calcium content. Administration of the proposed therapeutic and prophylactic complex contributed to correction of these disturbances and normalisation of the studied parameters towards the values observed in intact animals, indicating increased mineral content of alveolar bone and enhanced bone turnover.

Keywords:

bone destruction rats vitamin D deficiency alveolar bone

References:

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Publication:

«World of Medicine and Biology» Vol. 22 No. 97 (2026), pp. 196-200
UDC [57.084.1+611.018.4+616.314-002]:616-08-039.71

DOI:

https://doi.org/10.26724/2079-8334-2026-3-97-196-200