CENTRAL AORTIC PRESSURE INDICES IN YOUNG WOMEN WITH EXCESSIVE BODY WEIGHT AND ARTERIAL HYPERTENSION

Authors:

Abstract:

This study aimed to investigate changes in central aortic pressure and central hemodynamics, as well as tumor necrosis factor-α and C-reactive protein, in young women with arterial hypertension and excess body weight. The study included 43 young women, aged 18-40 (mean age 36.7±2.3 years), who were referred for an examination due to the detection of elevated blood pressure. Based on office and blood pressure measurements, individuals with persistent stage 1 arterial hypertension were divided into two groups: 20 women with normal body weight (group 1) and 23 women with excess body weight (group 2). The control group consisted of 20 women (mean age 36.5±2.7 years) with normal blood pressure and body weight. Young women with stage 1 arterial hypertension showed significantly greater increases in vascular stiffness and central aortic pressure than the control group. In women with stage 1 arterial hypertension and excess body weight, significantly higher values of central haemodynamic parameters were observed: systolic aortic pressure, diastolic aortic pressure, mean aortic pressure and pulse aortic pressure, as well as pulse wave velocity, compared to a group of patients with arterial hypertension and normal body weight. An increase in serum concentrations of tumor necrosis factor-α and C-reactive protein was observed in female patients with grade 1 hypertension, which was more pronounced in those with excess body weight, which confirms the role of inflammation in the pathogenesis of hypertension in the examined cohort of young women.

Keywords:

central aortic pressure tumor necrosis factor-α C-reactive protein arterial hypertension excess body weight young women

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Publication:

«World of Medicine and Biology» Vol. 21 No. 94 (2025) , с. 31-35
УДК 616.12-008.331.1-056.257-053.81-055.2

DOI:

https://doi.org/10.26724/2079-8334-2025-4-94-31-35