CORRECTION OF ELASTASE ACTIVITY IN THE ORAL FLUID OF PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS, OSTEOPENIA AND OSTEOPOROSIS USING A THERAPEUTIC AND PROPHYLACTIC COMPLEX

Authors:

Abstract:

The study was devoted to evaluating the effect of a therapeutic complex of drugs on elastase activity in the oral fluid of patients with chronic generalized periodontitis against a background of osteopenia and osteoporosis. Twenty-five adults (25–55 years) were allocated to three cohorts: an intact healthy control group, a comparison group receiving guideline-based mechanical and pharmacological periodontal therapy, and a main group receiving the same standard therapy supplemented with the therapeutic-prophylactic complex. These findings demonstrate that the therapeutic-prophylactic complex confers durable anti-inflammatory benefits beyond those achieved with conventional periodontal therapy alone, substantiating its promise as an adjunctive host-modulation strategy for patients with periodontitis and systemic bone loss.

Keywords:

chronic generalised periodontitis osteopenia osteoporosis elastase dental treatment therapeutic and prophylactic complex

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Publication:

«World of Medicine and Biology» Vol. 21 No. 94 (2025) , с. 46-50
УДК [616-053.88+616.71-007.234]:616.31-08-039.71

DOI:

https://doi.org/10.26724/2079-8334-2025-4-94-46-50