CHANGES IN EPIDEMIOLOGICAL INDICATORS DEPENDING ON THE ORGANIZATION OF TUBERCULOSIS TREATMENT

Authors:

Abstract:

With the purpose to investigate the impact of improving the effectiveness of tuberculosis treatment through the modernization of outpatient treatment on epidemiological indicators a comparative analysis of treatment effectiveness in 2 groups of patients, consisted of 50 newly diagnosed, drug-sensitive, unilaterally lung-affected, smear-positive, cavitary tuberculosis patients: Group 1 (who received the intensive phase of treatment in hospital and the continuation phase as outpatient care once every 10 days); Group 2 (who received treatment under strict daily supervision in a DOT room). It was found that the treatment success rate in the Group 2 was 98 %, exceeding that of the Group 1 by 18.4 %. Among patients of the Group 2, the rate of decrease in the components of infection allergy (increase in reaction compared to the previous year, conversion, and hyperergy to tuberculin) – was 1.1, 1.8, and 1.8 times higher respectively, compared to the Group 1.

Keywords:

directly observed therapy successful treatment tuberculosis infection morbidity among children and adolescents relapse

References:

1. Ağciyər vərəminin kimyəvi terapiyası üzrə klinik protokol (2-ci nəşr, yenilənmiş). Azərbaycan Respublikası Səhiyyə Nazirliyi. [Сlinical protocol for chemotherapy of pulmonary tuberculosis (2nd edition, updated). Ministry of Health of the Republic of Azerbaijan]. Baku. 2021. 81 p. [ın Azerbaijani]
2. Akhundova I. Dünyada və Azərbaycanda vərəmin epidemioloji vəziyyəti və ölkədə vərəmə qarşı görülən tədbirlər. İllik Hesabat. [Epidemiological Situation of Tuberculosis in the World and in Azerbaijan and Measures Taken Against Tuberculosis in the Country. Annual Report]. Baku, 2022, pp. 3–19. [ın Azerbaijani].
3. Brett K, Dulong C, Severn M. Treatment of Tuberculosis: A Review of Guidelines [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2020 Mar 6. PMID: 33074600.
4. Brett K, Severn M. Direct Observational Therapy for the Treatment of Tuberculosis: A Review of Clinical Evidence and Guidelines [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2020 Nov 24. PMID: 33523614.
5. Browne SH, Umlauf A, Tucker AJ, Low J, Moser K, Gonzalez Garcia J, et al. Wirelessly observed therapy compared to directly observed therapy to confirm and support tuberculosis treatment adherence: A randomized controlled trial. PLoS Med. 2019 Oct 4;16(10):e1002891. doi: 10.1371/journal.pmed.1002891.
6. European Centre for Disease Prevention and Control & World Health Organization. Regional Office for Europe. Tuberculosis surveillance and monitoring in Europe 2016: surveillance report. European Centre for Disease Prevention and Control & World Health Organization. Regional Office for Europe. 2016. 207 p. Available at: https://iris.who.int/handle/10665/374473.
7. Gadirova H. Dünyada və Azərbaycanda vərəmin epidemioloji vəziyyəti və ölkədə vərəmə qarşı görülən tədbirlər.İllik hesabat. [Epidemiological Situation of Tuberculosis in the World and in Azerbaijan and Measures Taken Against Tuberculosis in the Country. Annual Report]. Baku, 2021, pp. 3–10. [ın Azerbaijani].
8. Global Tuberculosis Report 2016. Geneva: World Health Organization; 2016. Available at: https://www.who.int/publications/i/item/9789241565394.
9. Guo P, Qiao W, Sun Y, Liu F, Wang C. Telemedicine Technologies and Tuberculosis Management: A Randomized Controlled Trial. Telemed J E Health. 2020 Sep;26(9):1150-1156. doi: 10.1089/tmj.2019.0190.
10. Gurbanova MB. Improvement of Methods for Early Detection, Monitoring, and Prevention of Tuberculosis Among Children and Adolescents. Author's abstract of the dissertation submitted for the degree of Doctor of Philosophy in Medicine. Baku, 2017. 26 p.
11. Huda MH, Rahman MF, Zalaya Y, Mukminin MA, Purnamasari T, Hendarwan H, et al. A meta-analysis of technology-based interventions on treatment adherence and treatment success among TBC patients. PLoS One. 2024 Dec 2;19(12):e0312001. doi: 10.1371/journal.pone.0312001.
12. Mhimbira F, Hella J, Maroa T, Kisandu S, Chiryamkubi M, Said K, et al. Home-Based and Facility-Based Directly Observed Therapy of Tuberculosis Treatment under Programmatic Conditions in Urban Tanzania. PLoS One. 2016 Aug 11;11(8):e0161171. doi: 10.1371/journal.pone.0161171.
13. Shikhaliev YSh. Vərəmli xəstələrin dispanser müşahidəsi, xəstəliklərin qarşısının alınması və epidemiya əleyhinə tədbirlər. In: Vərəm xəstəlikləri üzrə dərslik. [Dispensary Observation of Tuberculosis Patients, Disease Prevention and Anti-Epidemic Measures. In: Textbook on Tuberculosis Diseases]. Baku: Elm və Təhsil Publishing House, 2016, pp. 586–656. [ın Azerbaijani].
14. Zimmer AJ, Heitkamp P, Malar J, Dantas C, O'Brien K, Pandita A, et al. Facility-based directly observed therapy (DOT) for tuberculosis during COVID-19: A community perspective. J Clin Tuberc Other Mycobact Dis. 2021 Jun 25;24:100248. doi: 10.1016/j.jctube.2021.100248.

Publication:

«World of Medicine and Biology» Vol. 21 No. 94 (2025) , с. 83-88
УДК 616.24-002.5:614.2

DOI:

https://doi.org/10.26724/2079-8334-2025-4-94-83-88