NASAL CARRIAGE OF STAPHYLOCOCCUS AUREUS AMONG HEALTHCARE WORKERS IN KHARKIV MEDICAL FACILITIES

Authors:

Abstract:

The study was devoted to the problem of Staphylococcus aureus carriage among employees of medical institutions in Kharkiv in order to objectively investigate bacterial carriage as one of the causes of the spread of nosocomial infections. 309 employees of medical institutions in Kharkiv were examined. It was found that 31.7 % of those examined were carriers of S. aureus. Among all the isolated S. aureus isolates, 40 % were resistant to methicillin, and 3.5 % were resistant to vancomycin. To determine the routes of intrahospital spread of S. aureus and identify possible sources of infection, we performed phage typing on the isolated S. aureus isolates. It was found that in the surgical and somatic departments, S. aureus isolates of phage types 2 and 3 prevailed. This indicates their epidemiological significance. The results of our study on Staphylococcus aureus carriage among medical personnel in Kharkiv hospitals emphasize the need to establish systematic surveillance and preventive strategies aimed at reducing the risk of healthcare-associated infections.

Keywords:

nosocomial infections staphylococcal infections

References:

1. Bobrova NA, Vazhnichaya EM, Loban GA, Devyatkina TA, Lugovaya LA, Balyuk OYe, et al. Evaluation of susceptibility of reference strains of microorganisms to the combined action of essential oils and mexidol. World of medicine and biology 2021. № 2 (76). 173–178. DOI 10.26724/2079-8334-2021-2-76-173-178.
2. Bashabsheh RHF, Al-Fawares O, Natsheh, Bdeir R, Al-Khreshieh RO, Bashabsheh HHF. Staphylococcus aureus epidemiology, pathophysiology, clinical manifestations and application of nano-therapeutics as a promising approach to combat methicillin resistant Staphylococcus aureus. Pathogens and Global Health. 2024. Vol. 118(3). P. 209-231. doi:. PMID: 38006316; PMCID: PMC11221481. DOI: https://doi.org/10.1080/20477724.2023.2285187.
3. Bouiller K, Zeggay A, Gbaguidi-Haore H, Hocquet D, Chirouze C, Bertrand X. Epidemiology and risk factors of nasal carriage of Staphylococcus aureus CC398 in two distinct cohorts in France. Frontiers in Microbiology. 2022. Vol. 13. DOI: https://doi.org/10.3389/fmicb.2022.1068420.
4. Cella E, Sutcliffe CG, Tso C, Paul E, Ritchie N, Colelay J et al. Carriage prevalence and genomic epidemiology of Staphylococcus aureus among Native American children and adults in the Southwestern USA. Microbial Genomics. 2022. Vol. 8(5). PMID: 35551692; PMCID: PMC9465076. DOI: https://doi.org/10.1099/mgen.0.000806.
5. Chmielowiec-Korzeniowska A, Tymczyna L, Wlazło Ł, Nowakowicz-Dębek B, Trawińska B. Staphylococcus aureus carriage state in healthy adult population and phenotypic and genotypic properties of isolated strains. Postepy Dermatologii i Alergologii. 2020. Vol. 37(2). Р. 184–189. PMID: 32489352; PMCID: PMC7262795. DOI: https://doi.org/10.5114/ada.2020.94837.
6. Premanand B, Thiyagarajan S, Thangavelu S, Mohammed Ali S, George FS. A. Prevalence of Mupirocin and Methicillin-Resistant Staphylococcus aureus in Nasal Carriage Among Healthcare Workers in an Intensive Care Unit and Post-decolonization Screening Outcomes at a Tertiary Care Hospital: A Prospective Study. The Cureus Journal of Medical Science. 2023. Vol. 15(10). e46435. PMID: 37927697; PMCID: PMC10622254.DOI: https://doi.org/10.7759/cureus.46435.
7. Rai JR, Amatya R, Rai SK. Hand and nasal carriage of Staphylococcus aureus and its rate of recolonization among healthcare workers of a tertiary care hospital in Nepal. JAC-Antimicrobial Resistance. 2022. Vol. 4(3). PMID: 35668910; PMCID: PMC9160876. DOI: https://doi.org/10.1093/jacamr/dlac051.
8. Rossi СС, Ahmad F, Giambiagi-deMarval M. Staphylococcus haemolyticus: An updated review on nosocomial infections, antimicrobial resistance, virulence, genetic traits, and strategies for combating this emerging opportunistic pathogen. Microbiological Research. 2024. Vol. 282. 127652. DOI: https://doi.org/10.1016/j.micres.2024.127652.
9. Shih HI, Chang CM, Shen FC, Lee YJ, Wu CH, Hsu HC, Chi CY. High prevalence nasal carriage of methicillin-resistant Staphylococcus aureus among long term care facility healthcare workers in relation to patient contact. Infection Prevention in Practice. 2021. Vol. 3(1). 100117. PMID: 34368736; PMCID: PMC8336196.DOI: https://doi.org/10.1016/j.infpip.2021.100117.
10. Tobin EH, Zahra F. Nosocomial Infections. 2025 Aug 2. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025. Jan. PMID: 32644738. https://pubmed.ncbi.nlm.nih.gov/32644738/.
11. Touaitia R, Mairi A, Ibrahim NA, Basher NS, Idres T, Touati A. Staphylococcus aureus: A Review of the Pathogenesis and Virulence Mechanisms. Antibiotics. 2025. Vol. 14(5). P. 470.DOI: https://doi.org/10.3390/antibiotics14050470.

Publication:

«World of Medicine and Biology» Vol. 21 No. 94 (2025) , с. 89-93
УДК 579.864.1:616-097:579.61.2:616

DOI:

https://doi.org/10.26724/2079-8334-2025-4-94-89-93