EFFECTS OF MONACOLIN K ON INFLAMMATION, OXIDATIVE STRESS, AND ENDOTHELIAL FUNCTION IN PATIENTS WITH MODERATE HYPERLIPIDEMIA

Authors:

Abstract:

The purpose to investigate the effect of a 12-week course of monacolin K and rosuvastatin on parameters of lipid profile, inflammatory markers, oxidative stress indices, and vascular function in patients with dyslipidemia. 60 patients with dyslipidemia were randomly divided into two equal groups: one group received monacolin K, the second one –rosuvastatin. Biomarkers were measured both before and after 12 weeks of treatment, including low-density lipoprotein cholesterol, high-sensitivity C-reactive protein, malondialdehyde, and intercellular adhesion molecule-1. Both groups showed statistically significant improvement compared to baseline (p<0.001). In the monacolin K group, low-density lipoprotein cholesterol decreased by 21.22 %, high-sensitivity C-reactive protein by 29.47 %, malondialdehyde by 21.85 %, and intercellular adhesion molecule-1 by 15.17 %. In the rosuvastatin group, the decreases were 40.4 %, 47.5 %, 40.4 %, and 29.9 %, respectively. Monacolin K exerted a marked beneficial effect on lipid metabolism, inflammation, oxidative stress, and vascular function biomarkers in dyslipidemic patients.

Keywords:

monacolin K rosuvastatin dyslipidemia low-density lipoprotein cholesterol high-sensitivity C-reactive protein malondialdehyde and intercellular adhesion molecule-1

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Publication:

«World of Medicine and Biology» Vol. 21 No. 94 (2025) , с. 112-116
УДК 615.244:616.151.5-008.64

DOI:

https://doi.org/10.26724/2079-8334-2025-4-94-112-116