EFFECT OF HYPOTHALAMIC PREOPTIC NUCLEUS ELECTRICAL ACTIVITY CHANGES ON GONADAL HORMONE REGULATION IN NORMAL AND EXTREME STATES

Authors:

Abstract:

With the purpose to examine the changes in the activity of gonadal hormones resulting from the effects of hydrogen sulfide gas and electrode implantation on the preoptic nucleus of the hypothalamus 35 female rabbits were observed. The activity of follicle-stimulating hormone, luteinizing hormone, and estradiol in the blood were evaluated after stress. On the 5th day follicle-stimulating hormone decreased by 0.26 IU/l; luteinizing hormone decreased by 0.18 IU/l, estradiol increased by 207.4 pg/ml (P<0.001) from the normal value. In the post-model period, electroencepfalografic waves and hormones do not return to normal levels. On the 30th day of gas exposure, follicle-stimulating hormone, luteinizing hormone, and estradiol decreased significantly (P<0.001). Thus, the preoptic nucleus of the hypothalamus has a complex structure that plays a key role in the regulation of the biological functions of the body and occupies an essential place in the endocrine regulation of the pituitary-gonadal system.

Keywords:

hypothalamus preoptic nucleus hormone hydrogen sulfide toxic and mechanical stress

References:

1. Alotiby A. Immunology of Stress: A Review Article. J Clin Med. 2024 Oct 25;13(21):6394. doi: 10.3390/jcm13216394.
2. Chen HJ, Ngowi EE, Qian L, Li T, Qin YZ, Zhou JJ, et al. Role of Hydrogen Sulfide in the Endocrine System. Front Endocrinol (Lausanne). 2021 Jul 16;12:704620. doi: 10.3389/fendo.2021.704620.
3. Ismayilov YuB, Salimli TA, Ismayilova AT, Iskandarova ZSh, Jafarova Q.K. The effect of lead acetate on the neuro-immuno- endocrine regulation of the organism and the number of hematological markers. World of medicine and Biology. 2023; 4 (86): 198-203. DOI: 10.26724/2079-8334-2023-4-86-198-202
4. Liang J, Liu QS, Ren Z, Min K, Yang X, Hao F, et al. Studying paraben-induced estrogen receptor- and steroid hormone-related endocrine disruption effects via multi-level approaches. Sci Total Environ. 2023 Apr 15;869:161793. doi: 10.1016/j.scitotenv.2023.161793.
5. Ma T, Li C, Nie Z, Miao H, Wu F. Regulatory Effect of Electroacupuncture on Hypothalamic Serotonin and its Receptor in Rats with Cerebral Ischemia. Current Neurovascular Research. 2023; 20(2), 237–243. https://doi.org/10.2174/1567202620666230612110156.
6. Negoiţă A-I, Amuzescu B, Mihăilescu DF, Bordea C. The Serotonergic System and Its Role in Thermoregulation. Physiologia. 2025; 5(4):37. https://doi.org/10.3390/physiologia5040037.
7. Oziol L, Alliot F, Botton J, Bimbot M, Huteau V, Levi Y, et al. First characterization of the endocrine-disrupting potential of indoor gaseous and particulate contamination: comparison with urban outdoor air (France). Environ Sci Pollut Res Int. 2017 Jan;24(3):3142-3152. doi: 10.1007/s11356-016-8045-7.
8. Pawlak K, Bojarski B, Jagusiak W, Wojnar T, Nieckarz Z, Arent Z, et al. An 1800 MHz Electromagnetic Field Affects Hormone Levels, Sperm Quality, and Behavior in Laboratory Rats (Rattus norvegicus). Applied Sciences. 2025; 15(9):5160. https://doi.org/10.3390/app15095160.
9. Saleem A, Awan T, Akhtar MF. A comprehensive review on endocrine toxicity of gaseous components and particulate matter in smog. Front Endocrinol (Lausanne). 2024 Jan 30;15:1294205. doi: 10.3389/fendo.2024.1294205.
10. Shahbazi-Gahrouei D, Setayandeh S, Aminolroayaei F, Shahbazi-Gahrouei S. Biological Effects of Non-ionizing Electromagnetic Fields on Human Body and Biological System: A Systematic Literature Review. Journal of Medical Sciences. 2018; 18: 149-156. DOI: 10.3923/jms.2018.149.156.
11. Solhjou KA, Hosseini SE, Vahdati A, Edalatmanesh MA. Changes in the Hypothalamic-Pituitary-Gonadal Axis in Adult Male Rats Poisoned with Proteus and Biscaya Insecticides. Iran J Med Sci. 2019 Mar;44(2):155-162.
12. Walker DM, Gore AC. Epigenetic impacts of endocrine disruptors in the brain. Front Neuroendocrinol. 2017 Jan; 44:1-26. doi: 10.1016/j.yfrne.2016.09.002.
13. Wallace SJ, de Solla SR, Head JA, Hodson PV, Parrott JL, Thomas PJ, et al. Polycyclic aromatic compounds (PACs) in the Canadian environment: Exposure and effects on wildlife. Environ Pollut. 2020 Oct;265(Pt B):114863. doi: 10.1016/j.envpol.2020.114863.

Publication:

«World of Medicine and Biology» Vol. 21 No. 94 (2025) , с. 172-178
УДК 612.43;612.018;615.252;591.147.4

DOI:

https://doi.org/10.26724/2079-8334-2025-4-94-172-178