English Ukrainian
Clinical medicine

STUDY OF THE ASSOCIATION OF POLYMORPHISMS OF CALCIUM METABOLISM AND BONE HOMEOSTASIS GENES WITH THE RISK OF ATHEROSCLEROSIS IN PATIENTS WITH GENERALIZED PERIODONTITIS

Published 2025-08-28

Authors:

H.O. Babenia
O.V. Dienha
S.A. Shnaider
G.V. Nikolayeva
O.E. Korniichuk
O.S. Dorohina
Abstract:
Genotyping of single nucleotide polymorphisms of several genes of calcium metabolism and bone homeostasis in patients with generalized periodontitis on the background of atherosclerosis atherosclerosis and in the control group was carried out. The association of the A allele of the rs6252 polymorphism of the PTH (parathyroid hormone) gene with the risk of atherosclerosis was revealed: OR=3.857 (95 % CI 1.243-11.968), the reliability of the χ2 value p=0.017. The homozygous AA genotype of this polymorphism was also associated with an increased risk of atherosclerosis in a recessive inheritance model (p=0.035). The experimental and control groups did not differ significantly in the distribution of frequencies of genotypes and alleles of polymorphisms rs1544410 of the VDR gene (vitamin D receptor), rs1801725 of the CASR gene (calcium-sensitive receptor), rs1126616 of the SPP1 gene (osteopontin), rs1801197 1377 C>T of the CTR gene (calcitonin receptor) and rs1801133 of the MTHFR gene (methylenetetrahydrofolate reductase).
Keywords:
atherosclerosis periodontitis calcium exchange bone homeostasis polymorphism genotyping
References:
  1. Baciu SF, Mesaroș AȘ, Kacso IM. Chronic Kidney Disease and Periodontitis Interplay – A Narrative Review. Int J Environ Res Public Health. 2023;20(2):1298. DOI: 10.3390/ijerph20021298.
  2. Björkegren JLM, Lusis AJ. Atherosclerosis: Recent developments. Cell. 2022; 185(10): 1630–1645. DOI: 10.1016/j.cell.2022.04.004.
  3. Cabrera CP, Ng FL, Nicholls HL, Gupta A, Barnes MR, Munroe PB, et al. Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated. Hum Mol Genet. 2019;28(R2):R151–R161. DOI: 10.1093/hmg/ddz197.
  4. Chang H, Wang Y, Zhang Z, Mi Z, Qiu X, Zhao M, et al. Association between periodontal disease and atherosclerosis: a bibliometric analysis. Front Cardiovasc Med. 2024;11:1448125. DOI: 10.3389/fcvm.2024.1448125.
  5. Hajishengallis G, Chavakis T. Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities. Nat Rev Immunol. 2021;21(7):426–440. DOI: 10.1038/s41577-020-00488-6.
  6. Hindy G, Aragam KG, Ng K, Chaffin M, Lotta LA, Baras A, et al. Genome-wide polygenic score, clinical risk factors, and long-term trajectories of coronary artery disease. Arterioscler Thromb Vasc Biol. 2020;40(11):2738–2746. DOI: 10.1161/ATVBAHA.120.314856.
  7. Libby P. The changing landscape of atherosclerosis. Nature. 2021; 592(7855): 524–533. DOI: 10.1038/s41586-021-03392-8.
  8. Ma S, Xie X, Yuan R, Xin Q, Yu M, Xiao S, et al Vascular aging and atherosclerosis: a perspective on aging. Aging Dis. 2025;16(1):33–48. DOI: 10.14336/AD.2024.0201-1.
  9. Nandini RD, Devi N, Gupta J, Singh N. Atherosclerosis: a review. Journal of Xidian University. 2024;18(3):1035–1059.
  10. Stutz C, Batool F, Petit C, Strub M, Kuchler-Bopp S, Benkirane-Jessel N, et al. Influence of parathyroid hormone on periodontal healing in animal models: a systematic review. Arch Oral Biol. 2020;120:104932. DOI: 10.1016/j.archoralbio.2020.104932.
  11. Walsh PS, Metzger DA, Higuchi R. Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. Biotechniques. 2013;54(3):134–139. DOI: 10.2144/000114018.
  12. Zardawi F, Gul S, Abdulkareem A, Sha A, Yates J. Association between periodontal disease and atherosclerotic cardiovascular diseases: revisited. Front Cardiovasc Med. 2021;7:625579. DOI: 10.3389/fcvm.2020.625579.
  13. Zhao T, Li Y, Tian J, Kang Y, Xu J, Shao H, et al. Unraveling the relationship between serum parathyroid hormone levels and trabecular bone score: a cross-sectional study. Sci Rep. 2024;14:13065. DOI: 10.1038/s41598-024-63979-9.
  14. Zhou B, Lu J, Beck JD, Moss KL, Prizment AE, Demmer RT, et al. Periodontal and other oral bacteria and risk of lung cancer in the Atherosclerosis Risk in Communities (ARIC) study. Cancer Epidemiol Biomarkers Prev. 2023;32(4):505–515. DOI: 10.1158/1055-9965.EPI-22-0601.
  15. Zhou M, Dong J, Zha L, Liao Y. Causal association between periodontal diseases and cardiovascular diseases. Genes. 2022;13(1):13. DOI: 10.3390/genes13010013.
Publication:
«World of Medicine and Biology» Vol. 21 No. 93 (2025) , с. 28-32
УДК 577.21:[616.13.002.2-004.6+616-053.9+616.311.2-002]
DOI:
https://doi.org/10.26724/2079-8334-2025-3-93-28-32