CHARACTERISTICS OF SMALL INTESTINE BIOCENOSIS AND THE IMPACT OF DISORDERS ON FUNCTIONAL DYSPEPSIA

Authors:

Abstract:

The purpose of the study to determine the prevalence of small intestinal bacterial overgrowth by conducting a lactulose breath test in patients with functional dyspepsia, to evaluate differences in clinical course of functional dyspepsia. To study the effectiveness of standard therapy (pantoprazole) and an approach with small intestinal bacterial overgrowth eradication (pantoprazole and rifaximin). Small intestinal bacterial overgrowth prevalence in the group with functional dyspepsia was significantly higher (p<0.038). Patients who had functional dyspepsia and small intestinal bacterial overgrowth overlap had higher scores on the modified symptom scale, corresponding to a more severe course compared to patients without small intestinal bacterial overgrowth. The obtained results show that intestinal dysbiosis in the form of small intestinal bacterial overgrowth worsens the course of both subtypes of functional dyspepsia and may act as one of the pathogenic links in its development.

Keywords:

functional dyspepsia small intestinal bacterial overgrowth rifaximin

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Publication:

«World of Medicine and Biology» Vol. 21 No. 93 (2025) , с. 141-146
УДК 616.33-008.6-06:616.341-022-039-085.33

DOI:

https://doi.org/10.26724/2079-8334-2025-3-93-141-146