CORRECTION OF BIOCHEMICAL MARKERS OF ANTIMICROBIAL DEFENSE AND BACTERIAL CONTAMINATION IN RAT GINGIVA INDUCED BY A MODEL OF PEROXIDATIVE PERIODONTITIS AND ALIMENTARY PROTEIN DEFICIENCY USING A THERAPEUTIC-PROPHYLACTIC COMPLEX

Authors:

Abstract:

The study assessed the impact of a newly developed therapeutic-prophylactic complex on indices of nonspecific antimicrobial defence (lysozyme activity) and bacterial contamination (urease activity, dysbiosis index) in gingival homogenates of rats subjected to a combined model of peroxidative periodontitis and alimentary protein deficiency. Thirty male Wistar rats were randomly assigned to three groups: an intact control, a combined-pathology group, and a combined-pathology group treated with the therapeutic-prophylactic complex. The therapeutic-prophylactic complex effectively prevented disruptions of antimicrobial homeostasis and substantially restored the microbiological balance of periodontal tissues under conditions of protein-oxidative stress, underscoring its potential as a prophylactic agent for nutrition-related periodontal injuries.

Keywords:

periodontitis protein deficiency rats experiment biochemical markers

References:

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Publication:

«World of Medicine and Biology» Vol. 21 No. 93 (2025) , с. 167-171
УДК [57.084.1+616-08-039.71]:616.311.2

DOI:

https://doi.org/10.26724/2079-8334-2025-3-93-167-171