MODULATION OF MONOAMINERGIC NEUROTRANSMISSION RESTORES MNESTIC IMPAIRMENTS IN RATS WITH CHRONIC UNPREDICTABLE STRESS

Authors:

Abstract:

The purpose of the study was to investigate the expression of learning and memory processes in rats in chronic unpredictable stress dynamics in conditions of serotoninergic, dopaminergic and adrenergic neurotransmitter systems activity modulation. Experimental studies were performed on the model of chronic unpredictable stress on Wistar rats with previously induced the serotoninergic, dopaminergic and noradrenergic neurotransmitter systems activity activation and suppression. Animals’ ability to learn and their short- and long-term memory expression were determined in the dynamics of used model, The data obtained confirm the expressed mnestic disorders development in rats during the chronic unpredictable stress manifested by deterioration of learning, memory engrams formation and preservation. Mnestic disorders were shown to be developed from the 1st day of chronic unpredictable stress induction, progressed in its dynamics and were maximally expressed from the 14th day of the trial. Serotonin, dopamine and adrenergic neurotransmission suppression starting from the 7th day of the trial significantly impaired rats learning and short- and long-term memory and their activation on 21st day of the trial resulted in mnestic dysfunctions normalization. The authors stressed on monoaminergic neurotransmission functional activity accounting while analyzing the persons cognitive capabilities in chronic stress conditions. The data obtained are experimental evidence of monoaminergic neurotransmission activation clinical effects testing reasonability in chronic stress conditions while performing the treatment regimens for mnestic disorders pathogenetic therapy in patients with chronic unpredictable stress.

Keywords:

chronic unpredictable stress ischemia monoaminergic neurotransmission mnestic disorders conditioned reflexes learning memory pathophysiological mechanisms sanogenetic mechanisms

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Publication:

«World of Medicine and Biology» Vol. 21 No. 93 (2025) , с. 182-187
УДК 611.81/615:616.45-001.1/616.001/616.8

DOI:

https://doi.org/10.26724/2079-8334-2025-3-93-182-187