STUDY OF CHOLESTEROL CONTENT IN THE ORAL FLUID OF PATIENTS WITH PERI-IMPLANTITIS AGAINST THE BACKGROUND OF THE TREATMENT AND PREVENTION COMPLEX

Authors:

Abstract:

The study was devoted to researching of the effect of the treatment and prevention complex on the cholesterol content in the oral fluid of patients with peri-implantitis. The study involved 40 patients with peri-implantitis aged 25 to 55 years. Indicators of oral lipid metabolism – cholesterol – were determined in the patients' oral fluid. In patients receiving the treatment and prevention complex, the level of cholesterol in the oral fluid decreased by 25 % after one month of therapy compared to the baseline. After three months, it decreased by another 2.1 times, approaching the level observed in healthy individuals. In patients in the comparison group, who received only the standard treatment protocol, the level of cholesterol in the oral fluid remained persistently elevated throughout the study period, which emphasizes the need for additional interventions to achieve a significant normalization of lipid metabolism in peri-implantitis.

Keywords:

oral fluid health of the oral cavity implants treatment and prevention complex adult patients

References:

1. Makarenko OA, Khromahina LM, Khodakov IV. Metody doslidzhennya stanu kyshkovyka ta kistok u laboratornykh shchuriv: dovidnyk. Odesa: Odeskyy natsionalnyy universytet im. I.I. Mechnykova, 2022. 81 p. [in Ukrainian].
2. Rohach IM, Keretsman AO, Sitkar AD. Pravylno vybranyy metod statystychnoho analizu – shlyakh do yakisnoyi interpretatsiyi danykh medychnykh doslidzhen. Naukovyy visnyk Uzhhorodskoho universytetu, seriya “Medytsyna”. 2017;2(56):124–128. [in Ukrainian].
3. Adubetska AY, Dienha OV, Dienga AE, Verbytska TH, Shnaider SA, Pyndus TO, et al. Genetic predisposition to peri-implantitis and thrombosis in dental implants. World of Medicine and Biology. 2023;2(84):7–11. DOI: 10.26724/2079-8334-2023-2-84-7-11.
4. Canullo L, Peñarrocha M, Monje A, Catena A, Wang HL, Peñarrocha D. Association Between Clinical and Microbiologic Cluster Profiles and Peri-implantitis. Int J Oral Maxillofac Implants. 2017;32(5):1054–1064. DOI: 10.11607/jomi.6043.
5. Canullo L, Radovanović S, Delibasic B, Blaya JA, Penarrocha D, Rakic M. The predictive value of microbiological findings on teeth, internal and external implant portions in clinical decision making. Clin Oral Implants Res. 2017;28(5):512–519. DOI: 10.1111/clr.12828.
6. Darby I. Risk factors for periodontitis & peri-implantitis. Periodontol 2000. 2022;90(1):9–12. DOI: 10.1111/prd.12447.
7. Fi C, Wo W. Periodontal disease and systemic diseases: an overview on recent progresses. J Biol Regul Homeost Agents. 2021;35(1 Suppl. 1):1–9.
8. Halstenbach T, Nelson K, Iglhaut G, Schilling O, Fretwurst T. Impact of peri-implantitis on the proteome biology of crevicular fluid: A pilot study. J Periodontol. 2023;94(7):835–847. DOI: 10.1002/JPER.22-0461.
9. Lumbikananda S, Srithanyarat SS, Mattheos N, Osathanon T. Oral Fluid Biomarkers for Peri-Implantitis: A Scoping Review. Int Dent J. 2024;74(3):387–402. DOI: 10.1016/j.identj.2023.11.005.
10. Marcantonio C, Nicoli LG, Marcantonio Junior E, Zandim-Barcelos DL. Prevalence and Possible Risk Factors of Peri-implantitis: A Concept Review. J Contemp Dent Pract. 2015;16(9):750–7. DOI: 10.5005/jp-journals-10024-1752.
11. Zhuang LF, Watt RM, Mattheos N, Si MS, Lai HC, Lang NP. Periodontal and peri-implant microbiota in patients with healthy and inflamed periodontal and peri-implant tissues. Clin Oral Implants Res. 2016;27(1):13–21. DOI: 10.1111/clr.12508.

Publication:

«World of Medicine and Biology» Vol. 21 No. 91 (2025) , с. 7-10
УДК [616-053.81+616.314-089.843]:616.31-08-039.71

DOI:

https://doi.org/10.26724/2079-8334-2025-1-91-7-10