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Experemental medicine

MORPHOMETRIC CHARACTERISTICS OF THE MAIN STRUCTURAL COMPONENTS OF THE POSTERIOR EYE WALL IN RATS UNDER THE IMPACT OF A COMPLEX OF MONOSODIUM GLUTAMATE, SODIUM NITRITE AND PONCEAU 4R

Published 2025-03-12

Authors:

G.A. Yeroshenko
K.V. Shevchenko
V.A. Synenko
A.S. Grygorenko
S.V. Kononenko
I.M. Zviaholska
V.V. Onipko
Abstract:
The paper presents the results of a morphometric study of the components of the posterior wall of the rat eye under the complex effect of food additives. It has been established that the endogenous effect of the complex of sodium glutamate, sodium nitrite and Ponceau-4R causes significant morphometric changes in the structures of the retina, which proves their neurotoxic properties on retinal cells and is expressed by a progressive decrease in morphometric parameters in the chronological aspect. These changes indicate the development of degenerative changes that can affect visual functions, causing their deterioration and confirm the need to limit the consumption of food additives to reduce the risks associated with visual impairment.
Keywords:
food additives monosodium glutamate sodium nitrite Ponceau 4R retina eye rats
References:
  1. Lisnianska NV, Novak–Mazepa KhO, Kopanytsia OM, Mialiuk OP, Pak AI. Vyvchennia efektiv poiednanoi dii kharchovykh dobavok. Visnyk medychnykh i biolohichnykh doslidzhen. 2020; 2: 88-90. [in Ukrainian].
  2. Malieiev VO, Bezpalchenko VM, Semenchenko OO. Kharchovi dobavky: vyznachennia, ryzyky, analiz spozhyvannia. Vcheni zapysky TNU imeni V.I. Vernadskoho. Seriia: tekhnichni nauky. 2020; (2(3): 7-12. [in Ukrainian].
  3. Shpihelkhalter D. Mystetstvo statystyky. Pryiniattia arhumentovanykh rishen na osnovi danykh. Kyiv : KM-Buks. 2023. 384 s. [in Ukrainian].
  4. Abd-Elkareem M, El-Rahman A, Mokhless A, Khalil NSA, Amer AS. Antioxidant and cytoprotective effects of Nigella sativa L. seeds on the testis of monosodium glutamate challenged rats. Sci. Rep. 2021; 11: 13519. doi: 10.1038/s41598-021-92977-4.
  5. Airaodion AI, Ogbuagu EO, Osemwowa EU, Ogbuagu U, Esonu CE. Toxicological Effect of Monosodium Glutamate in Seasonings on Human Health. Glob. J. Nutri. Food Sci. 2019, 1, 522. DOI: 10.33552/GJNFS.2019.01.000522.
  6. Banerjee A, Mukherjee S, Maji BK. Worldwide flavor enhancer monosodium glutamate combined with high lipid diet provokes metabolic alterations and systemic anomalies: An overview. Toxicol. Rep. 2021; 8: 938–961. doi: 10.1016/j.toxrep.2021.04.009.
  7. Bera TK, Kar SK, Yadav PK, Mukherjee P, Yadav S, Joshi B. Effects of monosodium glutamate on human health: A systematic review. World Journal of Pharmaceutical Sciences, 2017; 5(5): 139-144.
  8. Kay R. Fast Facts: Medical Statistics: Understanding clinical trial results. Karger Publishers Limited. 2020. 108 p.
  9. Kris Gunnars. Are Nitrates and Nitrites in Foods Harmful? Healthline [updated Febr 10, 2020; cited 2020 Nov 24]. Available from: https://www.healthline.com/nutrition/are-nitrates-and-nitrites-harmful]/
  10. Nnadozie JO, Chijioke UO, Okafor OC, Olusina DB, Oli AN, Nwonu PC еt al. Chronic toxicity of low dose monosodium glutamate in albino Wistar rats. BMC Res. Notes. 2019; 12: 593. doi: 10.1186/s13104-019-4611-7.
  11. Pronina OM, Koptev MM, SM Bilash SM, Yeroshenko GA. Response of hemomicrocirculatory bed of internal organs on various external factors exposure based on the morphological research data. World of Medicine and Biology. 2018; 1(63): 153-57.
  12. Shevchenko KV, Yeroshenko GA, Yakushko OS, Kazakova KS, Kramarenko DR. Morphometric description of the exchange segment of microvasculature of rats’ salivary glands in normal conditions and chronic ethanol intoxication. Wiadomości Lekarskie. 2019; 72(3): 323-26.
  13. Valluzzi RL, Fierro V, Arasi S. Allergy to food additives. Curr Opin Allergy Clin Immunol. 2019;19(3):256-62. doi: 10.1097/ACI.0000000000000528.
  14. Yachmin AI, Kononov BS, Yeroshenko GA, Bilash SM, Bilash VP. Ameasure of the effect of complex food additives on rats’adaptive responses. World of Medicine and Biology. 2020; 1(71): 232-235. DOI: 10.26724/2079-8334-2020-1-71-232-235.
  15. Yamasaki M, Mishima HK, Yamashita H, Kashiwagi K, Murata K, Minamoto A, Inaba T. Neuroprotective effects of erythropoietin on glutamate and nitric oxide toxicity in primary cultured retinal ganglion cells. Brain Res. 2005 Jul 19; 1050(1-2): 15-26. doi: 10.1016/j.brainres.2005.05.037. PMID: 15979589.
Publication:
«World of Medicine and Biology» Vol. 21 No. 91 (2025) , с. 167-172
УДК 617.7:612.08:599.323.4
DOI:
https://doi.org/10.26724/2079-8334-2025-1-91-167-172