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    Dsyatsky V.V.

    SWIMMING BEHAVIOR AND AGGRESSIVENESS OF KINDLED RATS UNDER CONDITIONS OF NITROGEN OXIDE PRODUCTION MODULATION


    About the author: Dsyatsky V.V.
    Heading EXPERIMENTAL MEDICINE
    Type of article Научная статья
    Annotation Reduced variablity of kindled rats swimming was reversed by L- arginine (500 mg/kg, i.p.) by 19,0% pertained to that one detected in kindled not- treated animals (control). L- arginine and L-NAME did not influence the variability of intact rats swimming. The increased threshold of kindled rats escape from water pool was reversed by L- arginine (200,0 and 500,0 mg/kg) by 65,3% and 119,7% correspondently. L-NAME (10,0 mg/kg) caused the threshold elevation by 71,2%. L- arginine induced the elevation while L-NAME decreased the threshold of intact rats escape – correspondently by 22,4 and 37,5% when used in maximal dosages. Kindling- induced reduction of the aggressive reactions threshold was reversed by L-arginine (500,0 mg/kg) by 29,0%. L-NAME (10,0 mg/kg) suppressed the threshold of animal fights by 23,3%. L- arginine (500,0 mg/kg) when used in intact rats caused the elevation of the aggressive reactions threshold by 24,8%.
    Tags kindling, epileptic activity, swimming behavior, aggressiveness, nitrogen oxide
    Bibliography
    • Годлевский Л.С., Коболев Е.В., Мустяца В.Ф., Дроздова Г.А. Моделирование и механизмы подавления экспериментального эпилептического синдрома.- Одесса.- 2010.- 352 с.
    • Роль черной субстанции в противосудорожных и антиагрессивных эффектах диазепама при фармакологическом киндлинге / A.А.Шандра, Л.С.Годлевский, А.М.Мазарати [и др.] // Нейрофизиология.- 1990.- Т.22, №4.- С. 482- 485.
    • Inhibition of neuronal nitric oxide synthase increases aggressive behavior in mice/ G. E. Demas, M.J. Eliasson, T.M. Dawson et al. // Mol Med. 1997.- Vol. 3, N9.- P. 610–616.
    • Monti J.M. Microinjection of the nitric oxide synthase inhibitor L-NAME into the lateral basal forebrain alters the sleep/wake cycle of the rat/ J.M. Monti, H. Jantos // Progr.in Neuro-Psychopharm.and Biol. Psychiatry.- 2004.- Vol. 28, Issue 2.- P. 239- 247.
    • Pleiotropic contributions of nitric oxide to aggressive behavior/ R.J.Nelson, B.C.Trainor, S.Chiavegatto, G.E.Demas// Neurosci. Biobehav. Rev.- 2006.- Vol.30, N3.- P. 346- 355.
    • Saransaari P. Modulation of GABA release by second messenger substances and NO in mouse brain stem slices under normal and ischemic conditions / P.Saransaari, S.S.Oja // Neurochem.Res.- 2006.- Vol.31, N11.- P. 1317-1325.
    • Sleep and epilepsy: A key role for nitric oxide?/ H.Faradji, C.Rousset, G.Debilly et al.// Epilepsia.- 2001.- Vol. 41, N7.- P. 794- 801.
    • Vrijmoed-de Vries M.C. Differential effects of striatal injections of dopaminergic, cholinergic and GABAergic drugs upon swimming behavior of rats/ M.C.Vrijmoed-de Vries, A.R.Cools // Brain Res.- 1986.- Vol.364, N1.- P. 77-90
    • West A.R. Striatal nitric oxide signaling regulates the neuronal activity of midbrain dopamine neurons in vivo/ A.R. West, A.G.Anthony // J. Neurophysiol.- 2000.- Vol.83.- P. 1796-1808.
    • Yildirim M. Endothelial nitric oxide synthase activity involves in the protective effect of ascorbic acid against penicillin-induced epileptiform activity/ M.Yildirim, M.Ayyildiz, E.Agar//  Seizure: European Journal of Epilepsy.- 2010.- Vol. 19, N2.- P.102-108.
    Publication of the article «World of Medicine and Biology» №1(28), 2011 year, 14-18 pages, index UDK 612.821.7+ 616.853