Kolesnikova O.V.

DEPENDENS OF PHENOTYPIC PATTERN NONALCOHOLIC FATTY LIVER DISEASE ON POLYMORPHISM IN GENE ADIPOR1

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About the author:	Kolesnikova O.V.
Heading	CLINICAL MEDICINE
Type of article	Научная статья
Annotation	In article results which testify that have a predisposition to development nonalcoholic fatty liver disease (NAFLD) in the patients with metabolic infringements are presented. It is caused by authentic association alleles and genotypes of a polymorphic marker of gene ADIPOR1 at NAFLD patient's. It is established that SNP in promoters' gene ADIPOR1 associated at NAFLD patient's with the raised maintenance of liver fat, development of and insulin resistance, and higher levels HbA1c and GGTP. The knowledge of pheno-/genotype features at NAFLD patient's is necessary for a choice of individual algorithm of treatment.
Tags	nonalcoholic fatty liver disease, adipocytokine, polymorphism in gene ADIPOR1
Bibliography	Adiponectin and its receptors are expressed in bone forming cells / H.S. Berner, S.P. Lyngstadaas, A. Spahr [et al.] // Bone. – 2004. -V. 35ю – Р. 842–849. Balmer M.L. Significance of serum adiponectin levels in patients with chronic liver disease / M.L.Balmer, J.Joneli, A. Schoepfera // Clinical Science. – 2010. – V. 119. –P. 431–436 . Civitarese A.E. Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of type 2 diabetes / A.E.Civitarese, C.P.Jenkinson, D. Richardson // Diabetologia. – 2004. – V. 47. – Р. 816–820. Collins S.C. Adiponectin receptor genes:0
Publication of the article	«World of Medicine and Biology» №4(31), 2011 year, 94-98 pages, index UDK 616.36-004 .2-092:575