РусскийEnglishУкраїнська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    Torgalo L.О., Таburets О.V., Beregova T.V., Ostapchenko L.I., Yankovsky D.S.

    ALANINE AMINOTRANSFERASE ACTIVITY IN RATS OF DIFFERENT AND IN CONDITIONS OF PERIODICAL INJECTION OF MULTIPROBIOTIC «SYMBITER® ACIDOPHILIC»


    About the author: Torgalo L.О., Таburets О.V., Beregova T.V., Ostapchenko L.I., Yankovsky D.S.
    Heading EXPERIMENTAL MEDICINE
    Type of article Научная статья
    Annotation It was established, that activity of alanine aminotransferase in serum is decreasing in rats with age (from 3 to 18 months). Periodical administration (every 3 months during 10 days) to the rats multiprobiotic "Symbiter® acidophilic" prevents the age-related changes in the enzyme activity. Thus activity of alaninaminotranspherase may be serve as biomarker of aging and periodical use of multiprobiotic may to some extent prevent age-related changes in activity of alanine aminotransferase.
    Tags ontogenesis, alanine aminotransferase, multiprobiotic
    Bibliography
    • Торгало Є.О. Вплив мультипробіотика «Симбітер® ацидофільний» на вміст продуктів перекисного окиснення ліпідів у сироватці крові та тканинах внутрішніх органів у щурів різного віку / Є.О.Торгало,
      Т.В. Довбинчук, Л.І. Остапченко // Вісник Київського національного університету імені Тараса Шевченка. Серія Проблеми регуляції фізіологічних функцій. – 2011. - № 14. – С. 46-47.
    • A community-based epidemiological study of elevated serum alanine aminotransferase levels in Kinmen. Taiwan / C-M. Liu, T-H Tung [ et al].  // World J Gastroenterol. – 2005. – Vol. 11. – P. 1616-1622.
    • Dong M.H. Alanine Aminotransferase decreases with Age: The Rancho Bernardo Study / M.H Dong, R. Bettencourtz, E. Barrett-Connorz // Plos ONE. - plosone.www.org. – 2010. – V. 5, Issue 12. – e14254.
    • Correlation between serum alanine aminotransferase activity and age: an inverted U curve pattern / E. Elinav, I.Z. Ben-Dov [et al.] // Am J Gastroenterol. – 2005. – Vol. 100. – P. 2201-2204.
    • Hall K.E. American Gastroenterology Association Future trends Committee Report: Effects of aging of the population on gastroenterology practice, education and research / K.E.Hall, D.D.Proctor, L.Fisher // Gastroenterology. – 2005. – Vol. 129. – P. 1305-1308.
    • Ioannou G.N. The prevalence and predictors of elevated serum aminotransferase activity in the United States in 1992-2002 /  G.N. Ioannou,  E.J Boyako, S.P. Lee // Am J Gastroenterol. – 2006. – Vol. 101. – P. 66.-72.
    • Khedmat H. Serum g-glutamiltransferase, alanine aminotransferase, and aspartate aminotransferase activity in Iranian healthy blood donor men / H. Khedmat, F. Fallahian., В. Hajibeigi // World J Gastroenterol. – 2007. – Vol. 13. – P. 889-894.
    • Leclercq I. Influence of body mass index, sex and age on serum alanine aminotransferase (ALT) level in healthy blood donors/ I. Leclercq, Y. Horsmans, М. De Bruyere  // Acta Gastroenterol Belg. – 1999. – Vol. 62. – P. 16-20.
    • Le Couteur D.G.The association of alanine transaminasewith aging, frailty, and mortality/ D.G. Le Couteur, F.M. Blyth, H.M. Creasey   // J Gerontol A Biol Sci Med Sci. – 2010. – Vol. 65. – P. 712-717.
    • Liangpunsakul S. Unexplained elevations in alanine aminotransferase in individuals with the metabolic syndrome: Results from the third national health and nutrition survey (NHANES III) / S. Liangpunsakul, N. Chalasani  // Am J Med Sci. – 2005. – Vol. 329. – P. 111-116.
    • Mohamadnejad M. Healthy ranges of serum alanine aminotransferase levels in Iranian blood donors / М. Mohamadnejad, А. Pourshams, R. Malekzadeh. // World J Gastroenterol. – 2003. – Vol. 9. – P. 2322-2324.
    • Patt C.H. Prevalence of transaminase abnormalities in asymptomatic, healthy subjects participating in an executive health-screening program/ С.Н. Patt, H.Y Yoo, К. Dibadj // Dig Dis Sci – 2003. – Vol. 48. – P. 797-801.
    • Reevaluation of serum alanine aminotransferase upper limit and its modulation factors in a large-scale population study / R. Kariv, М. Leshno [et al.] // Liver International. – 2006. – Vol. 26. – P. 445-450.
    • Reitman S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvatic transaminases / S. Reitman, S. Frankel  // Am. J. Clin. Pathol. – 1957. – V. 28, N 1. – P. 56-63.
    • Ruhl C.E. Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States Ruhl C.E. Ruhl,  J.E.  Everhart // Gastroenterology. – 2003. – Vol. 124. – P. 71-79.
    Publication of the article «World of Medicine and Biology» №2(33), 2012 year, 163-166 pages, index UDK 612.66:612