Gavryluk A.O

HISTOLOGICAL AND IMMUNOHISTOCHEMICAL FEATURES OF PROBABLE PROGRESSION OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS B, C AND B + C

---

About the author:	Gavryluk A.O
Heading	EXPERIMENTAL MEDICINE
Type of article	Научная статья
Annotation	To determine the likely progression of portal-perisinusoidal fibrosis of the liver in patients with HVH B, C and B + C necessarily required identification of activated star-like cells in perisinusoidal spaces of the lobules of the liver and activated fibroblasts in portal tracts. Simultaneous expression of α-SMA activated perisinusoidal star-like cells and activated fibroblasts of portal tracts shows a high probability of development in the near future mixed portal – perisinusoidal liver fibrosis. Later in patients severe portal-perisinusoidal fibrosis is progressing, which can be revealed by staining of liver sections by van Hyzon and by trichromic method of Masson. In immunohistochemical studies was revealed the accumulation of collagen type IV in the portal tracts and also in perisinusoidal spaces of the liver lobules.
Tags	chronic viral hepatitis, fibrosis of the liver, immunohistochemical methods
Bibliography	Bataller R. Liver fibrosis / R. Bataller, D. A. Brenner // J. Clin. Invest. – 2005. – Vol. 115, № 2. – Р. 209-218. Friedman S.L. Liver fibrosis – from bench to bedside / S.L. Friedman // J. Hepatol. – 2003. – Vol. 38, Suppl. 1. – S. 38-53. Ghiassi-Nejad Z. Advances in Anti-fibrotic Therapy / Z. Ghiassi-Nejad, S.L. Friedman // Expert Rev. Gastroenterol. Hepatol. – 2008. – Vol. 2, № 6. – Р. 803-816. Hepatic myofibroblasts: a heterogeneous population of multifunctional cells in liver fibrogenesis / E. Novo, L.V. di Bonzo, S. Cannito [et al.] // Int. J. Biochem. Cell Biol. – 2009. – Vol. 41, № 11. – Р. 2089-2093. Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C / The French METAVIR Cooperative Study Group // Hepatology. –1994. – Vol. 20. – P. 15-20. Parola M. Hepatic wound repair / M. Parola, M. Pinzani // Fibrogenesis Tissue Repair. – 2009. – Vol. 25, № 2 (1). – P. 4-11. Pinzani M. Fibrosis in chronic liver diseases: diagnosis and management / M. Pinzani, K. Rombouts, S. Colagrande // J. Hepatol. – 2005. – Vol. 42. – S. 22-36.
Publication of the article	«World of Medicine and Biology» №3(34), 2012 year, 25-29 pages, index UDK 616.36–004:616