| About the author: |
Kozytska T.V., Chaikovsky Yu.B. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Научная статья |
| Annotation |
The research of CdS nanoparticles and cadmium chloride influence on mice brain embrional development was carried out. The morphological changes of new-born mice hippocampus which develop under the influence of cadmium were studied. It was established that CdS nanoparticles had pathological influence on the fetal hippocampus in different doses and caused cerebral edema and neuronal death in hippocampus. CdS nanoparticles had more expressed neurotoxic influence on new-born mice hippocampus, than cadmium chloride. Degree of CdS nanoparticles toxic effect was directly proportional to their dose and size. |
| Tags |
CdS nanoparticles, cadmium chloride, sodium polyphosphate, neurotoxicity, prenatal period |
| Bibliography |
- Васильев Д.С. Формирование конечного мозга крыс после нарушения эмбрионального развития, вызванного пренатальной гипоксией: Авт. дис. … канд.биол.наук: 03.00.13./03.00.25 / Д.С. Васильев. – СПб. – 2007. – 24 с.
- Влияние тиотриазолина на гистоморфологические изменения нейронов коры и гиппокампа в постинсультный период / И.Ф. Беленичев, И.А. Мазур, Ю.М. Колесник [и др.] // Новости медицины и фармации. – 2007. – 5 (209). – [Электронный ресурс]. – Режим доступа: http://novosti.mif-ua.com/archive/issue-3094/article-3189/
- Лихацький П.Г. Поєднаний вплив солей кадмію, кобальту та радіаційне опромінення на захисні системи тварин та шляхи корекції виявлених порушень / П.Г. Лихацький // Авт. дис. … канд. біол. наук: 03.00.04. – Львів. – 2007. – 22 с.
- Chan W.H. CdSe quantum dots induce apoptosis in human neuroblastoma cells via mitochondrial-dependent pathways and inhibition of survival signals / W.H. Chan, N.H. Shiao , P.Z. Lu // Toxicol Lett. – 2006. – Vol. 167. - № 3. – Р. 191-200.
- Hsieh M.S. Cytotoxic Effects of CdSe Quantum Dots on Maturation of Mouse Oocytes, Fertilization, and Fetal Development / M.S. Hsieh, N.H. Shiao, W.H. Chan // Int J Mol Sci. – 2009. – Vol. 10. - № 5. – Р. 2122-2135.
- Mechanisms of unmodified CdSe quantum dot-induced elevation of cytoplasmic calcium levels in primary cultures of rat hippocampal neurons / M. Tang, M. Wang, T. Xing [et al.] // Biomaterials. – 2008. – Vol. 29. - № 33. – Р. 4383-4391.
- Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability / E. Przybytkowski, M. Behrendt, D. Dubois [et al.] // FEBS J. – 2009. – Vol. 276. - № 21. – Р. 6204-6217.
- Unmodified CdSe quantum dots induce elevation of cytoplasmic calcium levels and impairment of functional properties of sodium channels in rat primary cultured hippocampal neurons / M. Tang, T. Xing , J. Zeng [et al.] // Environ. Health Perspect. – 2008. – Vol. 116. - № 7. – Р. 915-922.
|
| Publication of the article |
«World of Medicine and Biology» №3(34), 2012 year, 37-40 pages, index UDK 611.811.018.:546 |
