English Українська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    Podpalova O.M., Nurishenko N.E.

    MECHANISMS OF DEVELOPMENT OF ALCOHOL MYOPATHY IN SKELETAL MUSCLES


    About the author: Podpalova O.M., Nurishenko N.E.
    Heading LITERATURE REVIEWS
    Type of article Обзорная статья
    Annotation Alcoholic myopathy is considered as multifactor desease. Mechanisms, leading to muscle pathology of excessive alcohol consumption, have several options for implementation. Thus, the development of alcoholic myopathy is accompanied by changes in oxidation-reduction status and antioxidant disbalance in skeletal muscle. Chronic alcohol intake and acute alcohol intoxication can reduce the rate of protein synthesis, including miofibre proteins. Alcohol abuse leads to damage of signaling cascades, and increased apoptosis in skeletal muscle.
    Tags ethanol, alcohol, myopathy, protein synthesis, IL, oxidative stress
    Bibliography
    • Acute ethanol administration oxidatively damages and depletes mitochondrial DNA in mouse liver, brain, heart and skeletal muscles: protective effects of anti-oxidants. / Mansouri A, Demeilliers C, Amsellem S, Pessayre D, Fromenty B. J // Pharmacol Exp Ther. - 2007. - V. 298. - P. 737–743
    • Alcohol and indinavir adversely affect protein synthesis and phosphorylation of MAPK and mTOR signaling pathways in C2C12 myocytes. / Hong-Brown LQ, Brown CR, Huber DS, Lang CH // Alcohol Clin Exp Res. - 2006. - V. 30. - P. 1297–1307
    • Alcohol impairs leucine-mediated phosphorylation of 4E-BP1, S6K1, eIF4G, and mTOR in skeletal muscle. / Lang CH, Frost RA, DeshpandeN, Kumar V, Vary TC, Jefferson LS, Kimball SR // Am J Physiol Endocrinol Metab. - 2003. - V. 285. - P. E1205–E1215
    • Alcohol increases tumor necrosis alpha and decreases nuclear factor-kappab to activate hepatic apoptosis in genetically obese mice / Robin MA, Demeilliers C, Sutton A, Apradis V, Maisonneuve C, Dubois S, Poirel O, Letteron P, Pessayre D, Fromenty B. // Hepatology. – 2005. – V. 42. – P. 1280–1290.
    • Alcohol intoxication impairs phosphorylation of S6K1 and S6 in skeletal muscle independently of ethanol metabolism. / Lang CH, Pruznak AM, Deshpande N, Palopoli MM, Frost RA, Vary TC // Alcohol Clin Exp Res. - 2004. - V. 28. - P. 1758–1767
    • Alcoholic muscle disease and biomembrane perturbations. / Adachi J, Asaano M, Ueno Y, Niemela O, Ohlendieck K, Peters TJ, Preedy VR //  J Nutr Biochem. - 2003. - V. 14. - P. 616–625
    • Alcoholic myopathy: lack of effect of zinc supplementation. / Duraґn-Castelloґn MC, Gonzaґlez-Reimers E, Loґpez-Lirola A, Martıґn-Olivera R, Santolaria-Fernaґndez F, Galindo Martıґn L, Abreu-Gonzaґ lez P, Gonza ґlez-Hernaґndez T // Food Chemical Toxicol. - 2005. - V. 43. - P. 1333–1343
    • Carbohydrate ingestion influences skeletal muscle cytokine mRNA and plasma cytokine levels after a 3-h run. / Nieman DC, Davis JM, Henson DA, Walberg-Rankin J, Shute M, Dumke CL, Utter AC, Vinci DM, Carson JA, Brown A, Lee WJ, McAnulty SR, McAnulty LS. // Appl Physiol. - 2003. - V. 94. - P. 1917–1925
    • Chronic alpha-tocopherol supplementation in rats does not ameliorate either chronic or acute alcohol-induced changes in muscle protein metabolism. / Koll M, Beeso JA, Kelly FJ, Simanowski UA, Seitz HK, Petes TJ, Preedy VR //  Clin Sci (Lond). - 2003. - V. 104. - P. 287–294
    • Evidence of apoptosis in alcoholic cardiomyopathy. / Fernaґndez-Sola` J, Fatjoґ F, Sacanella E, Estruch R, Bosch X, Urbano-Maґ rquez A, Nicolas JM // Hum Pathol. - 2006. - V. 37. - P. 1100–1110
    • Expression of muscle uncoupling protein 3 mRNA in response to ethanol dosage. / Baffy G, Seitz H, Koll M, Preedy VR // Alcohol Clin Exp Res. - 2006. - V. 30(Suppl). - P. 147
    • Glutathione metabolism and its implications for health. /  Wu G, Fang YZ, Yang S et al.// The Journal of nutrition.  – 2004. – V.134. - P. 489-92
    • Hepatotoxicity of iron overload: mechanisms of ion-induced hepatic fibrogenesis / Ramm GA, Ruddell RG // Semin Liver Dis. – 2005. – V. 25. – P. 433–439.
    • Hydrogen peroxide causes greater oxidation in cellular RNA than in DNA. / Hofer T, Badouard C, Bajak E, Ravanat JL, Mattsson A, Cotgreave IA // Biol Chem. - 2005. - V. 386. - P. 333–337
    • Inhibition of store-operated Ca(2+) channels prevent ethanol-induced intracellular Ca(2+) increase and cell injury in a human hepatoma cell line. / Liu H, Jia X, Luo Z, Guan H, Jiang H, Li X, Yan M. // Toxicol Lett. - 2012. - V. Feb 208(3). - P. 254-61
    • IL-6 increases insulin stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMPK. / Carey AL, Steinberg GR, Macaulay SL, Thomas WG, Holmes AG, Ramm G, Prelovsek O, Hohnen-Behrens C, Watt MJ, James DE, Kemp BE, Pedersen BK, Febbraio MA. // Diabetes. - 2006. - V. 55. - P. 2688–2697
    • Interleukin-15 and other myokines in chronic alcoholics. / González-Reimers E, Fernández-Rodríguez CM, Santolaria-Fernández F, de la Vega-Prieto MJ, Martín-González C, Gómez-Rodríguez MÁ, Alemán-Valls MR, Rodríguez-Gaspar M // Alcohol  Epub. - 2011. - V. Jun 2.Sep-Oct; 46(5). - P. 529-33
    • Mechanisms of alcohol-induced tissue injury. / Molina PE, Hoek JB, Nelson S, Guidot D, David M, Lang Ch, Wands JR, Crawford JD // Alcohol Clin Exp Dis. - 2003. - V. 27. - P. 563–575
    • Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. / Brand MD, Affourtit C, Esteves TC, Green K, Lambert AJ, Miwa S, Pakay JL, Parker N Free // Radic Biol Med. - 2004. - V. 37. - P. 755 - 767
    • Molecular and cellular events in alcohol-induced muscle disease / Fernandez-Sola J, Preedy VR, Lang CH et al. // Alcohol Clin Exp Res. - 2007. - V. 31. - P. 1953–62
    • Muscle as an endocrine organ: focus on muscle-derived interleukin-6 / Pedersen BK, Febbraio MA // Physiological reviews. - 2008. – V. 88 (4). – P.  1379–406.
    • Procysteine stimulates expression of key anabolic factors and reduces plantaris atrophy in alcohol-fed rats / Otis JS, Guidot DM // Alcohol Clin Exp Res. – 2009. – V. 33. – P. 1450–9.
    • Protein and mRNA levels of the myosin heavy chain isoforms I[beta], IIa, IIx and IIb in Type I and Type II fibre-predominant rat  skeletal muscles in response to chronic alcohol feeding / Reilly ME, McKoy G, Mantle D, Peters TJ, Goldspink G, Preedy VR. // Muscle Res Cell Motil. – 2000. – V. 21. – P. 763–773.
    • Rapid rates of newly synthesized mitochondrial protein degradation are significantly affected by the generation of mitochondrial free radicals. / Basoah A, Matthews PM, Morten // KJ FEBS Lett. - 2005. - V. 579. - P. 6511–6517
    • Redox regulation of skeletal muscle. / Jackson MJ // IUBMB Life. - 2008. - V. 60. - P. 497–501
    • Relationship between ethanol-related diseases and nutritional status in chronically alcoholic men. / Estruch R, Nicolas JM, Villegas E, Junque A, Urbano-Marquez A // Alcohol Alcohol. - 1993. - V. 28. - P. 543–550
    • Restoration of protein synthesis in heart and skeletal muscle after withdrawal of alcohol / Vary TC, Nairn AC, Lang CH. // Alcohol Clin Exp Res. – 2004. – V.28. – P. 517–525.
    • Temporal differences in the ability of ethanol to modulate endotoxin-induced increases in inflammatory cytokines in muscle under in vivo conditions. / Frost RA, Nystrom G, Burrows PV, Lang CH // Alcohol Clin Exp Res. - 2005. - V. 29. - P. 1247–1256
    • The effect of high fat feeding on intramuscular lipid and lipid peroxidation levels in UCP3-ablated mice. / Hoeks J, Hesselink MK, Sluiter W, Schaart G, Willems J, Morrisson A, Clapham JC, Saris WH, Schrauwen P // FEBS Lett. - 2006. - V. 580. - P. 1371–1375
    • The effects of alcohol on skeletal and cardiac muscle / Urbano-Maґrquez A, Fernaґndez-Sola` J. // Muscle Nerve. – 2004. – V. 30. – P. 689–707.
    Publication of the article «World of Medicine and Biology» №3(34), 2012 year, 159-163 pages, index UDK 57.043:577