| About the author: |
Gadilia O.P., Ostapchenko L.I., Markevych A.O., Falalyeyeva T.M., Kudryavtsev K.V. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
It was conducted screening of synthesized low molecular organic compounds effectiveness in ulcer treatment on 224 white laboratory rats. It was established that the most effective low-molecular organic compound was KUD 259. It possessed the treatment effect on erosive and ulcerative lesions caused by all used models of experimental ulceration (stress, ethanol, indometacin and aspirin models). |
| Tags |
ulcer, screening, treatment, rats |
| Bibliography |
- ЗУ от 21.02.2006 № 3447-IV «Про защиту животных от жестокого обращения»: 2006.
- Філіпов Ю.О. Захворюваність основними хворобами органів травлення в Україні: аналітичний оглядофіційних даних Центру статистики МОЗ України / Ю.О. Філіпов // Гастроентерологія: міжвід. зб. - 2007. - № 38. - P.13-15.
- Bandyopadhyay D. Reactive oxygen species-induced gastric ulceration: protection by melatonin / Bandyopadhyay D., Chattopadhyay A. // Curr. Med. Chem. - 2006. - Vol.13, № 10. - P.1187-1202.
- Guide for the Care and Use of Laboratory Animals. - Washington DC: National Academy Press, 1996.
- Lassen A. The risk of missed gastroesophageal cancer diagnoses in user sandnonusers of antisecretory medication / A. Lassen, J. Hallas, de O.B. Muckadell // Gastroenterology. - 2005. - Vol.129, № 4. - P.1179-1186.
- Laine L. Gastric mucosal defense and cytoprotection: benchtobedside / L. Laine, K. Takeuchi, A. Tarnawski // Gastroenterology. - 2008. - Vol.135, № 1. - P.41-60.
- Ramesh S.T. Effect of central administration of ondansetron, a 5-hydroxytryptamine-3 receptor antagonist on gastric and duodenal ulcers / Ramesh S.T., Asad M., Dhamanigi S.S. [et al.] // Fundam. Clin. Pharmacol. - 2009. - Vol.23, № 3. - P.303-309.
- Shea-Donohue T. Aspirin-induced changes in gastric function: role of endogenous prostaglandins and mucosal damage / Shea-Donohue T., Steel L., Montcalm-Mazzilli E. [et al.] // Gastroenterology. - 1990. - Vol.98, № 2. - P.284-292.
- Seo P.J. Сomparison of indomethacin, diclofenac and aspirin-induced gastric damage according to ageinrats / P.J. Seo, N. Kim, J.H. Kim [et al.] // Gut Liver. - 2012. - Vol.6, № 2. - P.210-217.
- Takagi K. Studies on the drugs for peptic ulcer. A reliable method for producing stress ulcer in rats / K. Takagi, Y. Kasuya, K. Watanabe // Chem Pharm Bull (Tokyo). - 1964. - Vol.12, № - P.465-472.
- Takeuchi K. A new model of stress ulcer in the rat with pylorus ligation and its pathogenesis / K. Takeuchi, S. Okabe, K. Takagi // Am J Dig Dis. - 1976. - Vol.21, № 9. - P. 782-788.
- Tarnawski A.S. Molecular mechanisms of epithelial regeneration and neovascularization during healing of gastric and esophageal ulcers / A.S. Tarnawski, A. Ahluwalia // Curr. Med. Chem. - 2012. - Vol.19, № 1. - P.16-27.
- Wallace J.L. Prostaglandins, NSAIDs, and gastric mucosalт protection: why doesn't the stomach digest it self? / J.L. Wallace // Physiol. Rev. - 2008. - Vol.88, № 4. - P.1547-1565.
|
| Publication of the article |
«World of Medicine and Biology» №3(39) 1 part 2013 year, 016-020 pages, index UDK 616.342-002.44(043.3) |
