РусскийEnglishУкраїнська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    Gadilia O.P., Ostapchenko L.I., Markevych A.O., Falalyeyeva T.M., Kudryavtsev K.V.

    SCREENING OF SYNTHESIZED LOW MOLECULAR WEIGHT ORGANIC COMPOUNDS EFFECTIVENESS IN ULCER TREATMENT IN LABORATORY ANIMALS


    About the author: Gadilia O.P., Ostapchenko L.I., Markevych A.O., Falalyeyeva T.M., Kudryavtsev K.V.
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation It was conducted screening of synthesized low molecular organic compounds effectiveness in ulcer treatment on 224 white laboratory rats. It was established that the most effective low-molecular organic compound was KUD 259. It possessed the treatment effect on erosive and ulcerative lesions caused by all used models of experimental ulceration (stress, ethanol, indometacin and aspirin models).
    Tags ulcer, screening, treatment, rats
    Bibliography
    • ЗУ от 21.02.2006 № 3447-IV «Про защиту животных от жестокого обращения»: 2006.
    • Філіпов Ю.О. Захворюваність основними хворобами органів травлення в Україні: аналітичний оглядофіційних даних Центру статистики МОЗ України / Ю.О. Філіпов // Гастроентерологія: міжвід. зб. - 2007. - № 38. - P.13-15.
    • Bandyopadhyay D. Reactive oxygen species-induced gastric ulceration: protection by melatonin / Bandyopadhyay D., Chattopadhyay A. // Curr. Med. Chem. - 2006. - Vol.13, № 10. - P.1187-1202.
    • Guide for the Care and Use of Laboratory Animals. - Washington DC: National Academy Press, 1996.
    • Lassen A. The risk of missed gastroesophageal cancer diagnoses in user sandnonusers of antisecretory medication / A. Lassen, J. Hallas,  de O.B. Muckadell // Gastroenterology. - 2005. - Vol.129, № 4. - P.1179-1186.
    • Laine L. Gastric mucosal defense and cytoprotection: benchtobedside / L. Laine, K. Takeuchi,  A. Tarnawski // Gastroenterology. - 2008. - Vol.135, № 1. - P.41-60.
    • Ramesh S.T. Effect of central administration of ondansetron, a 5-hydroxytryptamine-3 receptor antagonist on gastric and duodenal ulcers / Ramesh S.T., Asad M., Dhamanigi S.S. [et al.] // Fundam. Clin. Pharmacol. - 2009. - Vol.23, № 3. - P.303-309.
    • Shea-Donohue T. Aspirin-induced changes in gastric function: role of endogenous prostaglandins and mucosal damage / Shea-Donohue T., Steel L., Montcalm-Mazzilli E. [et al.] // Gastroenterology. - 1990. - Vol.98, № 2. - P.284-292.
    • Seo P.J. Сomparison of indomethacin, diclofenac and aspirin-induced gastric damage according to ageinrats / P.J.  Seo, N. Kim, J.H.  Kim [et al.]  // Gut Liver. - 2012. - Vol.6, № 2. - P.210-217.
    • Takagi K. Studies on the drugs for peptic ulcer. A reliable method for producing stress ulcer in rats / K. Takagi, Y. Kasuya, K. Watanabe // Chem Pharm Bull (Tokyo). - 1964. - Vol.12, № - P.465-472.
    • Takeuchi K. A new model of stress ulcer in the rat with pylorus ligation and its pathogenesis / K. Takeuchi, S. Okabe, K. Takagi // Am J Dig Dis. - 1976. - Vol.21, № 9. - P. 782-788.
    • Tarnawski A.S. Molecular mechanisms of epithelial regeneration and neovascularization during healing of gastric and esophageal ulcers / A.S. Tarnawski,  A.  Ahluwalia // Curr. Med. Chem. - 2012. - Vol.19, № 1. - P.16-27.
    • Wallace J.L. Prostaglandins, NSAIDs, and gastric mucosalт protection: why doesn't the stomach digest it self? / J.L. Wallace // Physiol. Rev. - 2008. - Vol.88, № 4. - P.1547-1565.
    Publication of the article «World of Medicine and Biology» №3(39) 1 part 2013 year, 016-020 pages, index UDK 616.342-002.44(043.3)