| About the author: |
Levkovich N.M., Gorovenko N.H., Sheiko M.V. |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The results of determination of polymorphic variant C3435T of MDR1 gene in 144 patients with affective disorders (AD) and 103 healthy control people. A statistically significant difference between research groups for C3435T genotype [χ2=6,61, p=0,001, OR=0,51 (95% CI: 0,31-0,86)] and T3435T genotype [χ2=6,8, p=0,009, OR=2,22 (95% CI: 1,21-4,07)]. Was determined that the combination of C3435C and C3435T genotypes had protective value in in developing of AD [χ2=6,8, p=0,009, OR=0,45 (95% CI: 0,25-0,83)], while a presence of T3435T genotype increased risk of AD in 2 times with respect to control. As a result of our study, it was found an increased risk of AD compared with the control group for T3435T genotype of MDR1 gene. |
| Tags |
gene, polymorphism, affective disorders |
| Bibliography |
- Абрамов В.А. Социально-демографические особенности больных с первым депрессивным эпизодом / В.А. Абрамов, А.И. Жислин // – 2008. – №3 (20). – С.10-15.
- Вартанян М.Е. Современные проблемы генетики психиатрических заболеваний / М.Е. Вартанян // Проблемы медицинской генетики: сб. ст. – М., 1970. – С.495-509.
- Марута Н.О. Стан психічного здоров’я населення та психіатричної допомоги в Україні / Н.О. Марута // НейроNews. – 2010. – № 5 (24). – С.83-90.
- Полищук И.А. Шизофрения. / И.А. Полищук //- Киев: Здоровье, 1976., 262 с.
- Ben-Yehuda D. Therapy-related leukemia: сlinical characterstics and analysis of new molecular risk factors in 96 patients / D. Ben-Yehuda, S. Krichevsky, S. Shafran [et al.] // Blood. – 2002. – Vol.100. – 324 р.
- Drozdzik M. Polymorphism in the P-glycoprotein drug transporter MDR1 gene: a possible link between environmental and genetic factors in Parkinson’s disease / M. Drozdzik, M. Bialecka, K. Mysliwiec [et al.] // Pharmacogenetics. – 2003. – Vol.13, № 5. – P.259-263.
- Friedhoff A.J. Isolation and characterization of a compound from the urine of schizophrenics / A.J. Friedhoff, E. Van Winkle // Nature. – 1962. – Vol. 194. – Р.897-898.
- Furuno T. Expression polymorphism of the blood-brain barrier component P-glycoprotein (MDR1) in relation to Parkinson’s disease / T. Furuno, M.T. Landi, M. Ceroni [et al.] // Pharmacogenetics. – 2002. – Vol.12. – P.529-534.
- Functional C3435T polymorphism of MDR1 gene: an impact on genetic susceptibility and clinical outcome of childhood acute lymphoblastic leukemia / K. Jamroziak, W. Mlynarski, E. Balcerczak [et al.] // Eur. J. Haematol. – 2004. – Vol.72, № 5. – P.314-321.
- Heath R.G. Schizophrenia as an immunologic disorder / R.G. Heath, I.M. Krupp, L.W. Byers, J.I. Liljekvist // Arch. Gen. Psychiatry. – 1967. – Vol.16, №1. – Р.24-33.
- Hoffmeyer S. Functional polymorphisms of the human multidrug resistance gene: multiple bequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo / S. Hoffmeyer, O. Burk, O. von Richter [et al.] // Prnc. Nut1. Acud. Sci. USA. – 2000. – Vol. 97. –P.3473-3478.
- Latham L.K. Effect of a protein factor isolated from schizophrenic blood on permeability / L.K. Latham, K.Loncharich, K.A. Warner [et al.] // Vox Sanguinis. – 1963. – Vol.8, №4. – Р.491-496.
- Miller D.S. Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy / D.S. Miller, B. Bauer, A.M.S. Hartz // Pharmacol. Rev. – 2008. – Vol.60. – P.196-209.
- Nurnberger J.I. Jr. A simulated genetic structure for bipolar illness / J.I. Jr. Nurnberger // – 2008. – Vol. 147 (B). – P.952-956.
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| Publication of the article |
«World of Medicine and Biology» №3(39) 1 part 2013 year, 120-123 pages, index UDK 575.191:616.89-008:615.015.5 |
