| About the author: |
Silkina Yu.V. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
We investigated the human embryonic heart since 4th until 10 th weeks. Conductive cardiomyocytes identified via polyclonal antibodies: NF (LabVision) and neuregulin (LabVision). It is else one evidence about development conjugation of the nervous and conduction systems in the heart. So, the degree of the heart’s conductive system structural components differentiation has a positive correlation with the relative volume index of nerve fibers that it includes. The growth direction of the atrioventricular bundle fibers depends on the vector distribution of nerve fibers in the interventricular septum. Purkinje fibers express neuregulin that paracrine way regulates of the heart’s nervous system development. |
| Tags |
conductive system, heart, cardiomyocytes, neurofilaments, neuregulin, human embryo |
| Bibliography |
- Антомонов М. Ю. Математическая обработка и анализ медико-биологических данных / М. Ю. Антомонов //-К., 2006.-558 с.
- Аритмии сердца. Терапевтические и хирургические аспекты : [библиотека врача специалиста].- М. : ГЭОТАР Медиа, 2009. - 400 с.
- Коровина Н.А. Клиническое значение малых аномалий развития сердца у детей / А. А. Тарасова, Т. М. Творогова // Лечащий врач.-2005.- № 4.-С. 47-49.
- Кушаковский М.С. Аритмии сердца : Расстройства сердечного ритма и проводимости. Причины, механизмы, электрокардиографическая и электрофизиологическая диагностика, клиника, лечение / М.С. Кушаковский //-СПб. : ООО «Издательство «Фолиант», 2007.-672 с.
- Crick S. Innervation of the human cardiac conduction system. A quantitative immunohistochemical and histochemical study / S. Crick, J. Wharton, M. Sheppard // Circulation.-1994.-Vol. 89.-P. 1697-1708.
- Christoffels V. Development of the pacemaker tissues of the heart / V. Christoffels, G. Smits, A. Kispert [et al.] // Circ. Res.-2010.-Vol. 106, № 2.- Р. 240-254.
- Gurjarpadhye A. Cardiac neural crest ablation inhibits compaction and electrical function of conduction system bundles / A. Gurjarpadhye, K. Hewett, C. Justus [et al.] // Am. J. Physiol. Heart Circ. Physiol.- 2007.-Vol. 292, № 3.- Р. 1291-1300.
- Hildreth V. Cells migrating from the neural crest contribute to the innervation of the venous pole of the heart / V. Hildreth, S. Webb, L. Bradshaw [et al.] // J. Anat.-2008.-Vol. 212, № 1.- Р. 1-11.
- Patel R. Endothelin-1 and Neuregulin-1 convert embryonic cardiomyocytes into cells of the conduction system in the mouse / R. Patel, L. Kos // Dev. Dyn.-2005.-Vol. 145.-P. 452-459.
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| Publication of the article |
«World of Medicine and Biology» №3(40) 2 part 2013 year, 017-019 pages, index UDK 616.12:611.018.835:611.89:611.013.395 |
