Haninа E.I.

THE EPIDEMIOLOGICAL AND CLINICAL CHARACTERISTICS OF ENDOMETRIAL HYPERPLASIA WITH CHRONIC ENDOMETRITIS IN PREMENOPAUSAL WOMEN

---

About the author:	Haninа E.I.
Heading	CLINICAL MEDICINE
Type of article	Scentific article
Annotation	The goal of the work was to determine the epidemiological and clinical characteristics of the endometrial hyperplastic processes with chronic endometritis in premenopausal women. Were prospectively studied 224 premenopausal women with different morphological types of hyperplasia with chronic endometritis; furthermore, 2570 medical records was retrospectively analyzed. As a result, epidemiological data, history, data of instrumental, laboratory and morphological investigations was summarized. Found that more often than other cervical mucus, which was taken for analysis in all subjects, without exception, contain human papilloma virus, cytomegalovirus, fungal infections caused by candida albicans, and mixed infection (both - viral and bacterial). The most frequent clinical symptoms of hyperplastic processes with the chronic endometritis in premenopausal women are duration and amount of menstrual bleeding. Found that the risk appearance of atypical hyperplasia in premenopausal women with chronic endometritis significantly increased when combined the following factors: the low level of fertility, the use an intrauterine device for more than 5 years, the presence of urogenital infections, diseases of the cardiovascular system, excess weight, decreased immunity, increased concentration blood gonadotropic hormones, increased estrogen and decreased progesterone and testosterone in the blood.
Tags	endometrial hyperplasia, chronic endometritis, premenopausal women
Bibliography	Ахметова Е.С. Роль инфекций и хронического воспаления в патогенезе гиперпластических процессов эндометрия  / Е.С. Ахметова, Т.Е. Белокриницкая, Н.Н. Чарторижская // Проблемы репродукции (спец. выпуск). - 2009. – С. 167-168. Берштейн Л. М. Эпидемиология, патогенез и пути профилактики рака эндометрия: стабильность или эволюция? / Л.М. Берштейн // Практич. онкол. – 2004. – Т. 5, № 1. – С. 1–8. Квашенко В. П. Влияние метаболического синдрома на формирование клинической картины неатипической гиперплазии эндометрия в пременопаузе / В.П. Квашенко, М.В. Борисов // Репродуктивное здоровье женщины. - 2007. - № 2. - С. 158-162. Куценко И. И. Инфекционные и иммунные факторы в патогенезе гиперпластических процессов эндометрия / И.И. Куценко, Ю. С. Сафронова, А. Е. Хорольская // Мат. V регион. науч. фор. «Мать и дитя». – 2011. С. 227 – 228. Ditsworth D.  NF-kappaB: key mediator of inflammation-associated cancer / D. Ditsworth, W. Zong // Cancer Biol. Ther. – 2004. – Vol. 3, № 12. – Р. 1214-1216. Epplein M.  Risk of complex and atypical endometrial hyperplasia in relation to anthropometric measures and reproductive history / M. Epplein, S. Reed, L. Voigt [et al.] // Am. J. Epidemiol. – 2008. – Vol. 168. – P. 563–570. Lu H. Inflammation, a key event in cancer development / H. Lu, W. Ouyang, C. Huang // Mol. Cancer Res. – 2006. – Vol. 4. – P. 221–233.
Publication of the article	«World of Medicine and Biology» №3(40) 2 part 2013 year, 046-048 pages, index UDK 611.664+618. 173:576.2+616-018