EnglishУкраїнська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    Mykytyuk M.R., Khizhnyak O.O.

    LEPTIN’s LEVEL AND ITS RELATIONSHIP TO ANTHROPOMETRICAL PARAMETERS IN PATIENTS WITH ACROMEGALY


    About the author: Mykytyuk M.R., Khizhnyak O.O.
    Heading CLINICAL MEDICINE
    Type of article Scentific article
    Annotation The study involved 60 patients with active acromegaly. Shown that leptin levels in patients with acromegaly, regardless of gender associated with both BMI and from Fat,%; leptin levels in women are also associated with OT and OS. In the total sample of patients with acromegaly were found significant effect of excessive production of growth hormone and IRF -1 production of leptin and its sexual dimorphism. The level of leptin significantly associated with the level of growth hormone in the blood only in women. The level of leptin in patients with somatotropinomoyu leptin level is associated with the level of PRL levels.
    Tags acromegaly, growth hormone, insulin-like growth factor -1, prolactin, leptin
    Bibliography
    • Ali A.T. Adipocyte and adipogenesis / A.T. Ali, W.E. Hochfeld, R. Myburgh [et al.] // – 2013. – Vol. 92, № 6-7. – Р. 229-236.
    • Bolanowski M. Serum leptin levels in acromegaly-a significant role for adipose tissue and fasting insulin/glucose rati / M. Bolanowski, A. Milewicz, B. Bidzińska [et al.] / Med. Sci. Monit. – 2002. – Vol. 8, № 10. – Р. 685-689.
    • Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) // JAMA. – 2001. – Vol. 285, № 19. – P. 2486-2497.
    • Gómez J.M. Interactions between serum leptin, the insulin-like growth factor-I system, and sex, age, anthropometric and body composition variables in a healthy population randomly / J.M. Gómez , F.J. Maravall, N. Gómez, [et al.] // - Clin. Endocrinol. (Oxf.). – 2003. – Vol. 58, № 2. – Р. 213-219.
    • Isozaki O. Interaction (GH)/IGF-I between Leptin Axis in and Growth Hormone / O. Isozaki, T. Tsushima, M. Miyakawa [et al.] // Endocrine J. – 1999. – Suppl. 46. – S.17-24.
    • Melmed S. Guidelines for Acromegaly Management: An Update / S. Melmed, A. Colao, A. Barkan [et al.] / J. Clin. Endocrinol. Metabol. – 2009. – Vol. 94, № 5. – Р. 1509-1517.
    • Melmed S. Diagnosis & treatment of hyperprolactinemia: An Endocrine Society Clinical Practice Guideline / S. Melmed, F. Casanueva, R. Andrew [et al.] //J. Clin. Endocrinol. Metabol. – 2011. – Vol. 96, № 2. – Р. 273-288.
    • Ostadrahimi A. Correlates of serum leptin and insulin-like growth factor-I concentrations in normal weight and overweight/obese Iranian women / A. Ostadrahimi, T. Moradi, N. Zarghami [et al.] / J. Womens Health (Larchmt). – 2008. – Vol. 17, № 8. – P. 1389-1397.
    • Söderberg S. High leptin levels are associated with stroke / S. Söderberg, B. Stegmayr, C. Ahlbeck-Glader [et al.] / Cerebrovasc. Dis. – 2003. – № 15. – Р. 63–69.
    • Sattar N. Leptin and coronary heart disease: prospective study and system- atic review / N. Sattar, G. Wannamethee, N. Sarwar [et al.] // J. Am. Coll. Cardiol. – 2009. – № 53. – Р. 167–175.
    • World Health Organization. Obesity: Preventing and managing the global epidemic: Technical report series no. 894. – Geneva : WHO, - 2000. – 23р.
    • Hursting S. Obesity, energy balance, and cancer: new opportunities for prevention / S. Hursting, J. Digiovanni, A. Dannenberg [et al.] / Cancer. Prev. Res. (Phila). – 2012. – Vol. 5, № 11. – Р. 1260-1272.
    • Khafaji H. Elevated serum leptin levels in patients with acute myocardial infarction; correlation with coronary angiographic and echocardiographic findings / H. Khafaji, А. Bener, N. Rizk [et al.] // - BMC Res. Notes. – 2012. – Vol. 29, № 5. – Р. 262.
    • Saad M. Sexual dimorphism in plasma leptin concentration M. Saad/ M. Saad, S. Damani, R. Gingerich [et al.] /J. Clin. Endocrinol. Metab. – 1997. – Vol. 82, № 2. – Р. 79-84.
    • Silha J. Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance / J. Silha, M. Krsek, J.V. Skrha [et al] / Eur. J. Endocrinol. – 2003. – № 149. – Р. 331–333.
    • Seravalle G. Decreased adrenergic tone in acromegaly: evidence from direct recording of muscle sympathetic nerve activity / G. Seravalle, C. Carzaniga, R. Attanasio [et al.] / Clin. Endocrinol. (Oxf.). – 2012. – Vol. 77, № 2. – Р. 262-267.
    Publication of the article «World of Medicine and Biology» №1(43), 2014 year, 045-049 pages, index UDK 616.432:616-006:616.71-007.152:616-007.61:612.433.664