English Українська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    Belikova M. V., Zinevich J. V., Lutsenko A.V., Krasnova S. P., Pastuchova V. A.

    CHANGES OF THE MAINTENANCE OF CATECHOLAMINES, POL AND ANTIOXIDANT SYSTEM IN BLOOD PLASMA WHEN AGEING


    About the author: Belikova M. V., Zinevich J. V., Lutsenko A.V., Krasnova S. P., Pastuchova V. A.
    Heading CLINICAL MEDICINE
    Type of article Scentific article
    Annotation Concentration increase HMM against activation of the SOD and KAT antioxidant enzymes in plasma of blood of elderly people testifies to strengthening of an oxidizing stress when aging. The lowered maintenance of noradrenaline in blood plasma at people of advanced age, specifies on reduction of activity of a neyronalny peripheral link of simpatoadrenalovy system. Simultaneous increase the maintenance of DOFA when aging shows decrease of the activity of enzymes of the subsequent synthesis of catecholamines. Therefore, the organism of the elderly person doesn't possess sufficient resistance for overcoming of an oxidizing stress.
    Tags catecholamines, blood antioxidant system
    Bibliography
    • Параніч А. В. Антиокислювальна активність тканин і ліпідів у щурів різного віку / А. В. Параніч, А. В. Копилов, А. Діарра [и др.] // Фізіол. Журн. - 1995. – Т. 41. - № 1-2. - С.29-36.
    • Фролькис В. В. Влияние зиксорина как индуктора микросомального окисления на теплопродукцию, активность антиоксидантной системы и продолжительность жизни старых крыс / В. В. Фролькис, Е. И. Жеребицкая, Х.nК. Мурадян // Пробл. стар. и долгол. - 1995. – Т. 5. - № 1-2. - С.18-26.
    • Alexander V.NG. Sympathtic neural reactivity to stress does not increase with age in healthy humans / V.NG. Alexander, R. Callister, D.G. Johnson [et al.] // Am. J. Physiol. -1994. - Vol. 267. - P. H344-H353.
    • Chance B. The nature of the catalase intermediate in the biological function / Chance B., Boveris A., Oshino N. [et al.] // - Baltimore: Univ. Park Press, - 1973.- P. 350-353.
    • Elroy-Stein O. Impaired neurotransmitter uptake in PC12 cells overexpression human Cu,Zn superoxide dismutase implication for gene dosage effects in Down syndrome / O. Elroy-Stein, Y. Groner // Cell.- 1988.- Vol.52.- P.259-267.
    • Esler M. D. Effects of Aging on the Resposiveness of the Human Cardiac Sympathetic Nerves to Sterssors / M. D. Esler, J. M. Thompson, D. M. Kaye [at al] // Circulation. -1995. -Vol.91, № 2. - P. 351-358.
    • Gardner H.W. Oxygen radical chemistry of polyunsaturated fatty acids / H. W. Gardner // Free Radic. Biol. Med. - 1989. – Vol. 7. - P.65-86.
    • Hashizume K. Free and total dopamine in human plasma: effect of posture, age and some pathophysiological conditions / K. Hashizume, A. Yamamoto, T. Ogihara // Hypertens. Res. - 1995. - Vol. 18 (Suppl 1). - P. S205-S207.,
    • Jacobwith P.M. Method for the rapid determination of norepinephrin, dopamine, serotonin, in the same brain region / P. M. Jacobwith, J. S. Richardson // Pharmacol.Biochem.Behavior. – 1979. – Vol.8. - № 5. – Р.515-519.
    • Ku H.-H. Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species / Ku H.-H., Brunk U.T., Sohal R.S.// Free Rad. Biol. Med.- 1993.- Vol.15.- P.621-627.
    • Koutsilieri E. Free radicals in Parkinson’s disease / E. Koutsilieri, C. Scheller, E.Grunblatt [et al.] // J.Neurol. – 2002. – Vol. 249. – № 2. – P. 1-5.
    • McCord J. M. Oxygen- derived radicals: A link between reperfusion injury and inflammation / J. M. McCord // Fed. Proc. - 1987. – Vol. 46. - P.2402-2406.
    • Murrel G.A.C. Modulation of fibroblast proliferation by oxygen free radicals / G.A.C. Murrel, M.J.O. Francis // Biochem. J. - 1990. - Vol. 265. - P. 659-665.
    • McCarty R. Regulation of Peripheral Catecholamine Responses to Acute Stress in Young Adult and Aged F-344 Rats / R. McCarty, K. Pacak, D.S . Goldstein [et al.] // Stress. -1997. - Vol. 2. - № 2. - P. 113-122.
    • Orr W.C. Effects of Cu,Zn superoxide dismutase overexpression on life span and resistence to oxidative stress in transgenic Drosophila melanogaster / W.C. Orr, R.S. Sohal // Arch. Biochem. Biophys. - 1993. – Vol. 301. - P. 34-40.
    • Whone A. L. Human bone marrow mesenchymal stem cells protect catecholaminergic and serotonergic neuronal perikarya and transporter function from oxidative stress by the secretion of glial-derived neurotrophic factor/ A. L. Whone, K. Kemp, M. Sun // Brain Res. – 2012. Jan 11, Vol. 1431, P.86-96.
    Publication of the article «World of Medicine and Biology» №4(46) 1 part 2014 year, 022-025 pages, index UDK 616. 152. 21 - 003. 96: 612. 67